69838-88-6Relevant academic research and scientific papers
NUMBER AND STRUCTURE OF SOLVOLYSIS INTERMEDIATES. PART 3. SN1 SOLVOLYSIS OF 2,2-DIMETHYL-1-(p-METHOXYPHENYL)PROPYL p-NITROBENZOATE: MECHANISM OF THE COMMON ION SALT EFFECTS ARISING AT THE STAGE OF THE SECOND ION-PAIR INTERMEDIATE
Kinoshita, Tomomi,Itoh, Masaaki,Shibayama, Koichi,Takeuchi, Ken'Ichi
, p. 234 - 243 (1994)
2,2-Dimethyl-1-(p-methoxyphenyl)propyl p-nitrobenzoate (ROPNB) was subjected to solvolysis in phenol in the presence of tetrabutylammonium -p-nitrobenzoate, in which the 'common ion rate depression' was confirmed to arise at the stage of the
Dynamic Carbon Isotope Exchange of Pharmaceuticals with Labeled CO2
Destro, Gianluca,Loreau, Olivier,Marcon, Elodie,Taran, Frédéric,Cantat, Thibault,Audisio, Davide
, p. 780 - 784 (2019/01/11)
A copper-catalyzed procedure enabling dynamic carbon isotope exchange is described. Utilizing the universal precursor [14C]CO2, this protocol allows to insert, in one single step, the desired carbon tag into carboxylic acids with no need of structural modifications. Reducing synthetic costs and limiting the generation of radioactive waste, this procedure will facilitate the access to carboxylic acids containing drugs and accelerate early 14C-based ADME studies supporting drug development.
Palladium-Catalyzed Carbon Isotope Exchange on Aliphatic and Benzoic Acid Chlorides
Gauthier, Donald R.,Rivera, Nelo R.,Yang, Haifeng,Schultz, Danielle M.,Shultz, C. Scott
supporting information, p. 15596 - 15600 (2018/11/23)
An operationally simple protocol for a palladium-catalyzed 13CO and 14CO exchange with activated aliphatic and benzoic carbonyls is presented. Several 13C and 14C building blocks, natural product derivatives, an
[14C] and [13C] labellings from N-(2-diethylaminoethyl)-4-iodobenzamide, and N-(3-deimethylaminopropyl)-4-iodobenzamide, melanoma tracers
Moreau,Parry,Bayle,Papon,Labarre,Veyre
, p. 805 - 813 (2007/10/02)
N-(2-diethylaminoethyl)-4-iodobenzamide (I) and N-(3-dimethylaminopropyl)-4-iodobenzamide (II), recently developed in our laboratory, are promising agents for metastatic melanoma detection in nuclear medicine. In order to study their 'in vivo' metabolism,
