699-11-6

Usage

Uses

Used in Pharmaceutical Industry:
N-(2-Bromoethyl)aniline serves as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new medications due to its unique chemical structure and reactivity.
Used in Dye Industry:
In the dye industry, N-(2-Bromoethyl)aniline is utilized for the production of dyes, capitalizing on its chemical properties to create a range of colorants for different applications.
Used in Organic Compounds Synthesis:
Beyond its applications in pharmaceuticals and dyes, N-(2-Bromoethyl)aniline is also employed in the synthesis of other organic compounds, highlighting its versatility in organic chemistry.

InChI:InChI=1/C8H10BrN/c9-6-7-10-8-4-2-1-3-5-8/h1-5,10H,6-7H2

Upstream product

• 106-93-4 ethylene dibromide 
• 62-53-3 aniline 
• 124-38-9 carbon dioxide 
• 122-98-5 2-Anilinoethanol 
• 41210-94-0 2-hydroxylethylphenylamine hydrochloride 

Downstream Products

• 696-18-4 1-phenylaziridine 
• 905306-38-9 (2-diphenylphosphanyl-phenyl)-(2-phenylamino-ethyl)-carbamic acid tert-butyl ester 
• 1001197-80-3 7-methyl-1-phenylindoline 
• 1450913-24-2 N¹-phenyl-N¹-(pyridin-2-ylmethyl)ethane-1,2-diamine 
• 423719-93-1 N-phenyl-N,N',N'-tris(2-pyridylmethyl)ethane-1,2-diamine 
• 1450913-16-2 C₂₇H₂₇N₅O 
• 1450913-17-3 C₃₄H₃₅N₆⁽¹⁺⁾ 
• 1450913-18-4 C₃₄H₃₅N₆⁽¹⁺⁾ 
• 1450913-19-5 C₃₈H₃₇N₆⁽¹⁺⁾ 
• 1450913-30-0 C₃₈H₃₇N₆⁽¹⁺⁾ 
• 1450913-31-1 C₃₉H₃₉N₆O⁽¹⁺⁾ 
• 174194-54-8 C₈H₁₀N₄ 
• 1491141-21-9 C₁₄H₁₅N₅ 
• 753491-58-6 4-(2-oxo-3-phenyl-imidazolidin-1-yl)-benzoic acid ethyl ester 

Relevant academic research and scientific papers

Synergetic activation of CO2by the DBU-organocatalyst and amine substrates towards stable carbamate salts for synthesis of oxazolidinones

The development of an efficient methodology to transform CO2 into valuable chemicals has attracted increasing attention concerning the challenging issues of CO2-utilization. Herein, an efficient approach for the preparation of oxazolidinones from CO2, primary (aliphatic/aromatic) amines and 1,2-dichloroethane (or its derivatives) catalyzed by DBU organo-superbase was achieved with yields of 47-97% under mild conditions (80-100 °C, 12 h, 1.0 MPa CO2). Control experiments demonstrated that the formation of an ion-pair carbamate salt intermediate IS-B derived from the reaction of CO2, DBU (catalyst) and an amine (substrate) was the key step for this three-component reaction. The available DBU-amine-CO2 adduct intermediate (like IS-B-2) with fair stability will evolve into the thermodynamically stable product oxazolidinones upon attack of 1,2-dichloroethane (or its derivatives), along with the regeneration of the DBU catalyst. Alternatively, the decomposition of the DBU-aryl amine-CO2 adduct (like IS-B-1) with relatively poor stability also could result in the competitive substitution reaction of 1,2-dichloroethane (or its derivatives) with the aryl amine. This work provides insights into synergetic CO2-activation by the DBU-catalyst and a nucleophilic amine-substrate via the formation of robust carbamate salt intermediates responsible for the final production of oxazolidinones. This journal is

Cationic N-substituted aniline ionic liquid and preparation method thereof

The invention discloses a cationic N-substituted aniline ionic liquid, wherein an N-substituted aniline structure is contained in positive ions, and preferably, the structure of the cationic N-substituted aniline ionic liquid is shown as formula (I). A preparation method of the cationic N-substituted aniline ionic liquid comprises the following steps: firstly preparing N-phenylethanolamine hydrobromide, then preparing N-phenylethanolamine bromide from N-phenylethanolamine hydrobromide, and finally reacting N-phenylethanolamine bromide with compounds as shown in formulas (II-1) to (II-14) to obtain the cationic N-substituted aniline ionic liquid. The cationic N-substituted aniline ionic liquid has the properties and applications of common ionic liquid (such as serving as a reaction medium,an additive of a polymer material and the like), can be used as a monomer, can also be used as a reaction monomer to prepare ionic liquid polyaniline derivative through self oxidative polymerization or oxidative copolymerization with other monomers, and can also be combined with other polymerization means (such as free radical polymerization and the like) to prepare ionic liquid polyaniline derivatives and compounds of the ionic liquid polyaniline derivatives and other polymers.

MACROCYCLIC INDOLE DERIVATIVES

The present invention relates to macrocyclic indole derivatives of general formula (I) : (I), in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Focused fluorescent probe library for metal cations and biological anions

A focused fluorescent probe library for metal cations was developed by combining metal chelators and picolinium/quinolinium moieties as combinatorial blocks connected through a styryl group. Furthermore, metal complexes derived from metal chelators having high binding affinities for metal cations were used to construct a focused probe library for phosphorylated biomolecules. More than 250 fluorescent probes were screened for identifying an ultraselective probe for dTTP.

Palladium-catalyzed domino C-C/C-N coupling using a norbornene template: Synthesis of substituted benzomorpholines, phenoxazines, and dihydrodibenzoxazepines

A rapid, four-step approach to alkyl- and aryl-substituted benzomorpholines is accomplished by a Pd-catalyzed domino C-C/C-N bond coupling using a norbornene template. Extension to phenoxazines and dihydrodibenzoxazepines is presented.

Design and synthesis of cyclic urea compounds: A pharmacological study for retinoidal activity

Retinoids are natural and synthetic analogues of all-trans retinoic acid (ATRA). Cancer and other serious hyperproliferative diseases are attractive therapeutic targets for retinoids. We report here the design and synthesis of novel cyclic urea compounds with retinoidal activity. YR105 exhibited potent differentiation-inducing ability toward human promyelocytic leukemia HL-60 cells at the concentration of 10-9M: its potency was almost equal to that of the native ligand, all-trans retinoic acid.

Triphenylphosphine/2,3-dichloro-5,6-dicyanobenzoquinone as a new, selective and neutral system for the facile conversion of alcohols, thiols and selenols to alkyl halides in the presence of halide ions

A mixture of triphenylphosphine (Ph3P) and 2,3-dichloro-5,6-dicyanobenzoquinone in CH2Cl2 affords a complex which in the presence of R4NX (X=Cl, Br, I) converts alcohols, thiols and selenols into their corresponding alkyl halides in high yields at room temperature. The method is highly selective for the conversion of 1° alcohols in the presence of 2° ones and also 1° and 2° alcohols in the presence of 3° alcohols, thiols, epoxides, trimethylsilyl- and tetrahydropyranyl ethers, 1,3 dithianes, disulfides, and amides.

Aminopiperidines, their production and the pharmaceutical compositions incorporating them

This invention relates to 4-aminopiperidines and more precisely to 4-aminopiperidines the nitrogen atom of the piperidine ring is substituted with an aryl lower alkyl side-chain. This invention also relates to processes for producing the same. This invention further extends to pharmaceutical compositions and to the method of using the same.