69959-88-2

Usage

Uses

Used in Organic Synthesis:
2-bromo-N,2-dimethyl-propanamide is utilized as a key building block in organic synthesis for the creation of various biologically active molecules. Its unique structure allows for the development of new compounds with potential applications in different fields.
Used in Pharmaceutical Research:
In pharmaceutical research, 2-bromo-N,2-dimethyl-propanamide is employed as an intermediate for the synthesis of pharmaceuticals. Its presence in the molecular structure of certain drugs contributes to their therapeutic effects, making it a valuable component in drug development.
Used in Agrochemical Production:
2-bromo-N,2-dimethyl-propanamide also finds application in the production of agrochemicals. As an intermediate, it plays a crucial role in the synthesis of compounds used in agriculture to protect crops and enhance yields.
Used in Drug Discovery and Development:
Due to its potential biological activities, 2-bromo-N,2-dimethyl-propanamide is of significant interest for further study in drug discovery and development. Researchers are exploring its properties to identify new therapeutic agents and improve existing treatments.

InChI:InChI=1/C5H10BrNO/c1-5(2,6)4(8)7-3/h1-3H3,(H,7,8)

Upstream product

• 20469-89-0 2-bromo-2-methylpropionyl chloride 
• 74-89-5 methylamine 
• 20769-85-1 2-bromoisobutyric acid bromide 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 91306-18-2 2-acetonyl-3,5,5-trimethyl-2-phenyloxazolidin-4-one 
• 128965-91-3 α-(4-chloro-phenoxy)-isobutyric acid methylamide 
• 88876-33-9 2-(1-bromo-1-methylethyl)-3,5,5-trimethyl-2-oxazolidin-4-one 
• 1101897-62-4 N,2,2-trimethyl-3-phenylpropanamide 
• 1428902-75-3 C₂₈H₃₉N₇O₃ 
• 88876-37-3 2,N-dimethyl-2-methylaminopropionamide 
• 128966-00-7 2-(2,6-Dimethyl-phenoxy)-2,N-dimethyl-propionamide 
• 128966-02-9 2-(2-Iodo-phenoxy)-2,N-dimethyl-propionamide 
• 128966-01-8 2-(2-Chloro-phenoxy)-2,N-dimethyl-propionamide 
• 128965-95-7 2,N-Dimethyl-2-phenoxy-propionamide 

Relevant academic research and scientific papers

NAPHTHYRIDINES AS INHIBITORS OF HPK1

Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE

Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. [Insert Formula Ic and Id]

PYRIMIDINE DERIVATIVES AS PI3K INHIBITORS

Thienopyrimidines of formula (Ia) or (Ib): wherein R1, R2, R3, are as defined in the claims.

PHARMACEUTICAL COMPOUNDS

Fused pyrimidines of formula (I); wherein A represents a thiophene or furan ring; n is 1 or 2; R1 is a group of formula (II); wherein m is 0 or 1; R30 is H or C1-C6 alkyl; R4 and R5 form, together with the N atom to which they are attached, a 5- or 6-membered saturated N-containing heterocyclic group which includes 0 or 1 additional heteroatoms selected from N, S and O, which may be fused to a benzene ring and which is unsubstituted or substituted; or one of R4 and R5 is alkyl and the other is a 5- or 6-membered saturated N-containing heterocyclic group as defined above or an alkyl group which is substituted by a 5- or 6-membered saturated N-containing heterocyclic group as defined above; R2 is selected from formula (a); wherein R6 and R7 form, together with the nitrogen atom to which they are attached, a morpholine, thiomorpholine, piperidine, piperazine, oxazepane or thiazepane group which is unsubstituted or substituted; and formula (b); wherein Y is a C2-C4 alkylene chain which contains, between constituent carbon atoms of the chain and/or at one or both ends of the chain, 1 or 2 heteroatoms selected from O, N and S, and which is unsubstituted or substituted; and R3 is an indazole group which is unsubstituted or substituted; and the pharmaceutically acceptable salt thereof have activity as inhibitors of P13K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with P13 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.

The Conversion of Phenols to Primary and Secondary Aromatic Amines via a Smiles Rearrangement

The conversion of phenols to 2-aryloxy-2-methylpropanamides (1) and the Smiles rearrangement of these to N-aryl-2-hydroxy-2-methyl propanamides are described; hydrolysis of the latter compounds yields anilines.The scope and limitations of reaction are discussed.Routes, some involving α-lactams, from phenols to N-substituted derivatives of (1) have been developed.Under the conditions of the Smiles rearrangement these secondary 2-methylpropanamides can form directly anilides, N-alkylanilines, or benzoxazinones.