69971-44-4

Usage

Uses

Used in Pharmaceutical Research:
4,6-DiMethylpyridin-3-carboxylic acid Methyl ester is used as an intermediate in the synthesis of various pharmaceutical compounds for its potential biological activities, including anti-inflammatory and anti-cancer properties.
Used in Agrochemical Research:
4,6-DiMethylpyridin-3-carboxylic acid Methyl ester is used as an intermediate in the synthesis of various agrochemical compounds, contributing to the development of new pesticides and other agricultural products.
Used in Drug Development:
4,6-DiMethylpyridin-3-carboxylic acid Methyl ester is used as a building block in the development of new drugs, leveraging its unique chemical structure and properties to create novel therapeutic agents.
Used in Drug Delivery Systems:
4,6-DiMethylpyridin-3-carboxylic acid Methyl ester is used in the development of drug delivery systems to improve the bioavailability and therapeutic outcomes of various pharmaceutical agents, taking advantage of its unique chemical properties to enhance drug efficacy and targeting.
Used in Organic Synthesis:
4,6-DiMethylpyridin-3-carboxylic acid Methyl ester is used as a key component in organic synthesis, enabling the creation of a wide range of chemical compounds for various applications across different industries.

Upstream product

• 646-06-0 1,3-DIOXOLANE 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 67-56-1 methanol 
• 6623-21-8 3-cyano-4,6-dimethylpyridine 
• 5470-70-2 Methyl 6-methylnicotinate 

Relevant academic research and scientific papers

Alcohols as alkylating agents in heteroarene C-H functionalization

Redox processes and radical intermediates are found in many biochemical processes, including deoxyribonucleotide synthesis and oxidative DNA damage. One of the core principles underlying DNA biosynthesis is the radical-mediated elimination of H2O to deoxygenate ribonucleotides, an example of 'spin-centre shift', during which an alcohol C-O bond is cleaved, resulting in a carbon-centred radical intermediate. Although spin-centre shift is a well-understood biochemical process, it is underused by the synthetic organic chemistry community. We wondered whether it would be possible to take advantage of this naturally occurring process to accomplish mild, non-traditional alkylation reactions using alcohols as radical precursors. Because conventional radical-based alkylation methods require the use of stoichiometric oxidants, increased temperatures or peroxides, a mild protocol using simple and abundant alkylating agents would have considerable use in the synthesis of diversely functionalized pharmacophores. Here we describe the development of a dual catalytic alkylation of heteroarenes, using alcohols as mild alkylating reagents. This method represents the first, to our knowledge, broadly applicable use of unactivated alcohols as latent alkylating reagents, achieved via the successful merger of photoredox and hydrogen atom transfer catalysis. The value of this multi-catalytic protocol has been demonstrated through the late-stage functionalization of the medicinal agents, fasudil and milrinone.

Steric and Conformational Effects in Nicotine Chemistry

The stereoselectivity of iodomethylation of nicotine and seven nicotine analogues having pyridine alkyl groups was determined by using 13C NMR.Alkylation at the pyridine (N) and at the pyrrolidine (N') nitrogens was observed.Two modes of N'-iodomethylation occur, cis and trans to the pyridine ring.N'-Iodomethylation occurs regioselectively cis to the pyridine ring for all compounds examined.The N/N' and N'cis/N'trans ratios for the nicotinoids were evaluated with regard to (1) the orientation of the N'-methyl group in the free base, (2) conformational properties of the pyridine ring with respect to the pyrrolidine ring, and (3) steric hindrance and buttressing effects on the pyridine nitrogen.The Curtin-Hammett principle and the Winstein-Holness equation are used to analyse reactions.