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700-76-5

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700-76-5 Usage

General Description

2-fluoro-2,3-dihydro-1H-inden-1-one is a chemical compound with the molecular formula C9H9FO. It is a fluoro-substituted indenone compound, which has a bicyclic structure containing a five-membered ring fused to a six-membered ring. 2-fluoro-2,3-dihydro-1H-inden-1-one is commonly used as a building block in the synthesis of various organic compounds, especially in the pharmaceutical industry. It exhibits potential as a key intermediate in the preparation of novel molecules with biological activity. The presence of a fluoro group in its structure can also impart unique properties and reactivity, making it valuable in the development of new chemical reactions and methodologies.

Check Digit Verification of cas no

The CAS Registry Mumber 700-76-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,0 and 0 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 700-76:
(5*7)+(4*0)+(3*0)+(2*7)+(1*6)=55
55 % 10 = 5
So 700-76-5 is a valid CAS Registry Number.

700-76-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-fluoro-2,3-dihydroinden-1-one

1.2 Other means of identification

Product number -
Other names 2-fluoroindan-1-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:700-76-5 SDS

700-76-5Relevant articles and documents

Direct Access to Chiral β-Fluoroamines with Quaternary Stereogenic Center through Cooperative Cation-Binding Catalysis

Vaithiyanathan, Venkataramasubramanian,Kim, Mun Jong,Liu, Yidong,Yan, Hailong,Song, Choong Eui

, p. 1268 - 1272 (2017)

A direct route to chiral β-fluoroamines with tetrasubstituted C?F centers through the organocatalytic Mannich reaction of α-fluoro cyclic ketones and α-amidosulfones by using a chiral oligoethylene glycol as a cation-binding catalyst and KF as a base is reported. For most substrates, nearly perfect enantioselectivities were achieved even at very high temperatures (>80 °C). The salient features of this process include a) a transition-metal-free and operationally simple procedure, b) direct use of α-amidosulfones as bench-stable precursors of sensitive imines, c) direct enolization of racemic α-fluoro cyclic ketones, and d) excellent stereoselectivity up to 99 % enantiomeric excess and >20:1 diastereoselectivity (anti/syn). Thus, this protocol is easily scalable and provides a new approach for the synthesis of biologically relevant products with tetrasubstituted C?F centers. Furthermore, this protocol was also successfully extended to generate C?Cl and C?Br quaternary stereogenic centers.

Method for synthesizing alpha-fluorinated ketone through hydrazone aliphatic chain monoketone

-

Paragraph 0086-0088, (2021/02/06)

The invention belongs to the technical field of organic synthesis, and provides a method for synthesizing alpha-ketone fluoride through hydrazone aliphatic chain monoketone, which comprises the following steps of: reacting aliphatic chain monoketone with hydrazine hydrate to obtain hydrazone, and reacting hydrazone with a compound represented by formula 2 under a heating condition to complete hydrazone defluorination. The fluorinated product is widely applied to medicines, the reaction conditions are mild, and the process is simple.

Flow electrochemistry: a safe tool for fluorine chemistry

Rennigholtz, Tim,Winterson, Bethan,Wirth, Thomas

, p. 9053 - 9059 (2021/07/12)

The heightened activity of compounds containing fluorine, especially in the field of pharmaceuticals, provides major impetus for the development of new fluorination procedures. A scalable, versatile, and safe electrochemical fluorination protocol is conferred. The strategy proceeds through a transient (difluoroiodo)arene, generated by anodic oxidation of an iodoarene mediator. Even the isolation of iodine(iii) difluorides was facile since electrolysis was performed in the absence of other reagents. A broad range of hypervalent iodine mediated reactions were achieved in high yields by coupling the electrolysis step with downstream reactions in flow, surpassing limitations of batch chemistry. (Difluoroiodo)arenes are toxic and suffer from chemical instability, so the uninterrupted generation and immediate use in flow is highly advantageous. High flow rates facilitated productivities of up to 834?mg h?1with vastly reduced reaction times. Integration into a fully automated machine and in-line quenching was key in reducing the hazards surrounding the use of hydrofluoric acid.

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