70015-76-8

Basic information

• Product Name: 1H-Pyrazole-3-carboxylic acid, 4-aMino-5-phenyl-, ethyl ester
• Synonyms: 1H-Pyrazole-3-carboxylic acid, 4-aMino-5-phenyl-, ethyl ester;ETHYL 4-AMINO-5-PHENYL-2H-PYRAZOLE-3-CARBOXYLATE;Ethyl 4-amino-3-phenyl-1H-pyrazole-5-carboxylate
• CAS NO: 70015-76-8
• Molecular Formula: C₁₂H₁₃N₃O₂
• Molecular Weight: 231.25052
• Mol File: 70015-76-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 145-146 °C(Solv: benzene (71-43-2))
• Boiling Point: 453.1°Cat760mmHg
• Flash Point: 227.8°C
• Appearance: /
• Density: 1.264g/cm³
• Vapor Pressure: 2.13E-08mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 14.26±0.50(Predicted)
• CAS DataBase Reference: 1H-Pyrazole-3-carboxylic acid, 4-aMino-5-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3-carboxylic acid, 4-aMino-5-phenyl-, ethyl ester(70015-76-8)
• EPA Substance Registry System: 1H-Pyrazole-3-carboxylic acid, 4-aMino-5-phenyl-, ethyl ester(70015-76-8)

Safety Data

• Hazardous Substances Data: 70015-76-8(Hazardous Substances Data)

Usage

Potential biological activities

anti-inflammatory and antitumor properties This indicates that the compound has shown potential for anti-inflammatory and antitumor activities, making it a target for further research and drug development.

InChI:InChI=1/C12H13N3O2/c1-2-17-12(16)11-9(13)10(14-15-11)8-6-4-3-5-7-8/h3-7H,2,13H2,1H3,(H,14,15)

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 140-29-4 phenylacetonitrile 
• 1224879-06-4 C₁₈H₁₆N₂O₄ 
• 1224879-08-6 C₁₈H₁₅ClN₂O₄ 
• 1224879-11-1 C₁₈H₁₆N₄O₂ 
• 1224879-13-3 3-(4-chlorophenyl)-4-phenylazo-1H-pyrazole-5-carboxylic acid ethyl ester 
• 70015-72-4 Ethyl-α-(hydroxyimino)benzopyruvat 
• 98-86-2 acetophenone 
• 99-91-2 para-chloroacetophenone 
• 5814-38-0 ethyl 4-chlorobenzoylpyruvate 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 169271-95-8 ethyl 4-phenyl-4-hydroximino-2-oxobutyrate 
• 70015-74-6 4-nitroso-5-phenyl-2H-pyrazole-3-carboxylic acid ethyl ester 

Downstream Products

• 91857-68-0 ethyl 4-dimethylamino-5-phenylpyrazole-(1H)-3-carboxylate 
• 91857-71-5 4-Amino-5-phenyl-1H-pyrazole-3-carboxylic acid 
• 891273-78-2 3-Phenyl-1H-pyrazolo[4,3-d]pyrimidine-5,7-diol 
• 885616-63-7 6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-3-phenyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one 
• 70015-80-4 3-phenyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 1370409-64-5 5-(2-ethoxyphenyl)-3-phenyl-1-(pyridin-3-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 
• 1370409-63-4 5-(2-ethoxyphenyl)-1,3-diphenyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 
• 1370409-60-1 5-(2-ethoxyphenyl)-3-phenyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 
• 1370409-66-7 2-(5-(2-ethoxyphenyl)-7-oxo-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-1-yl)acetamide 
• 91857-70-4 ethyl 4-dimethylamino-3-phenyl-1-methyl-(1H)-pyrazole-3-carboxylate 
• 91857-69-1 ethyl 4-dimethylamino-5-phenyl-1-methyl-(1H)-pyrazole-3-carboxylate 

Relevant articles and documents

Novel Substituted Purine Isosteres: Synthesis, Structure-Activity Relationships and Cytotoxic Activity Evaluation

A number of pyrrolo[2,3-c]pyridines, pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines were designed and synthesized as antiproliferative agents. The target compounds possessed selected substituents in analogous positions on the central scaffold th

Synthesis of new series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4-ones for their bacterial and cyclin-dependent kinases (CDKs) inhibitory activities

Two series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4- ones were designed, synthesised, and evaluated for their antibacterial activities and CDKs inhibitory activities. The pyridazine derivative: 6-phenyl-5-phenylhydrazono-2,3,4,5-tetrahydropyridazine- 3,4-dione (3a) revealed activity against Staphylococcus aureus as Gram-positive bacteria while compound 2-(2- Ethoxyphenyl-5-Phenylpiperazinosulfonamido)-3H-pyrido [2,3-d]pyrimidin-4-one (13c) was showing moderate antifungal activity against Candida albicans.

Convenient synthesis of 4-amino-3,5-disubstituted pyrazoles in one step from the corresponding diketo oximes

A convenient one-step protocol for the synthesis of 4-amino-3,5- disubstituted pyrazoles has been developed. This method employs readily available diketo oximes as starting materials, and employs hydrazine hydrate for the cyclization and subsequent reduct