70015-76-8

Usage

Potential biological activities

anti-inflammatory and antitumor properties This indicates that the compound has shown potential for anti-inflammatory and antitumor activities, making it a target for further research and drug development.

InChI:InChI=1/C12H13N3O2/c1-2-17-12(16)11-9(13)10(14-15-11)8-6-4-3-5-7-8/h3-7H,2,13H2,1H3,(H,14,15)

Upstream product

• 70015-72-4 Ethyl-α-(hydroxyimino)benzopyruvat 
• 1224879-13-3 3-(4-chlorophenyl)-4-phenylazo-1H-pyrazole-5-carboxylic acid ethyl ester 
• 1224879-11-1 C₁₈H₁₆N₄O₂ 
• 1224879-08-6 C₁₈H₁₅ClN₂O₄ 
• 1224879-06-4 C₁₈H₁₆N₂O₄ 
• 70015-74-6 4-nitroso-5-phenyl-2H-pyrazole-3-carboxylic acid ethyl ester 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 169271-95-8 ethyl 4-phenyl-4-hydroximino-2-oxobutyrate 
• 623-73-4 diazoacetic acid ethyl ester 
• 140-29-4 phenylacetonitrile 
• 98-86-2 acetophenone 
• 99-91-2 para-chloroacetophenone 
• 5814-38-0 ethyl 4-chlorobenzoylpyruvate 

Downstream Products

• 885616-63-7 6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-3-phenyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one 
• 70015-80-4 3-phenyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 
• 891273-78-2 3-Phenyl-1H-pyrazolo[4,3-d]pyrimidine-5,7-diol 
• 1370409-64-5 5-(2-ethoxyphenyl)-3-phenyl-1-(pyridin-3-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 
• 1370409-63-4 5-(2-ethoxyphenyl)-1,3-diphenyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 
• 1370409-60-1 5-(2-ethoxyphenyl)-3-phenyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 
• 1370409-66-7 2-(5-(2-ethoxyphenyl)-7-oxo-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-1-yl)acetamide 
• 91857-71-5 4-Amino-5-phenyl-1H-pyrazole-3-carboxylic acid 
• 91857-68-0 ethyl 4-dimethylamino-5-phenylpyrazole-(1H)-3-carboxylate 
• 91857-70-4 ethyl 4-dimethylamino-3-phenyl-1-methyl-(1H)-pyrazole-3-carboxylate 
• 91857-69-1 ethyl 4-dimethylamino-5-phenyl-1-methyl-(1H)-pyrazole-3-carboxylate 

Relevant academic research and scientific papers

Novel Substituted Purine Isosteres: Synthesis, Structure-Activity Relationships and Cytotoxic Activity Evaluation

A number of pyrrolo[2,3-c]pyridines, pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines were designed and synthesized as antiproliferative agents. The target compounds possessed selected substituents in analogous positions on the central scaffold th

ISOTHIAZOLOPYRIMIDINONES, PYRAZOLOPYRIMIDINONES, AND PYRROLOPYRIMIDINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.

Synthesis of new series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4-ones for their bacterial and cyclin-dependent kinases (CDKs) inhibitory activities

Two series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4- ones were designed, synthesised, and evaluated for their antibacterial activities and CDKs inhibitory activities. The pyridazine derivative: 6-phenyl-5-phenylhydrazono-2,3,4,5-tetrahydropyridazine- 3,4-dione (3a) revealed activity against Staphylococcus aureus as Gram-positive bacteria while compound 2-(2- Ethoxyphenyl-5-Phenylpiperazinosulfonamido)-3H-pyrido [2,3-d]pyrimidin-4-one (13c) was showing moderate antifungal activity against Candida albicans.

Novel bicyclic heterocyclic compounds, process for their preparation and compositions containing them

The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.

Convenient synthesis of 4-amino-3,5-disubstituted pyrazoles in one step from the corresponding diketo oximes

A convenient one-step protocol for the synthesis of 4-amino-3,5- disubstituted pyrazoles has been developed. This method employs readily available diketo oximes as starting materials, and employs hydrazine hydrate for the cyclization and subsequent reduct