70015-80-4

Usage

Uses

Used in Pharmaceutical Industry:
7H-Pyrazolo[4,3-d]pyrimidin-7-one, 1,6-dihydro-3-phenylis used as a pharmaceutically relevant molecule for its potential therapeutic applications. 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 1,6-dihydro-3-phenylis being studied for its biological activities and pharmacological properties, which may contribute to the development of new drugs for the treatment of various medical conditions.
Used in Drug Development:
In the field of drug development, 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 1,6-dihydro-3-phenylis utilized for its potential to be a key component in the creation of new medications. Ongoing research aims to understand its pharmacological effects and how it can be leveraged to address specific health issues, making it a valuable asset in the advancement of medical treatments.

Upstream product

• 3473-63-0 formamidine acetic acid 
• 98-80-6 phenylboronic acid 
• 98-86-2 acetophenone 
• 99-91-2 para-chloroacetophenone 
• 5814-38-0 ethyl 4-chlorobenzoylpyruvate 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 1224879-06-4 C₁₈H₁₆N₂O₄ 
• 70015-76-8 4-amino-3-phenyl-1H-pyrazole-5-carboxylic acid ethyl ester 

Downstream Products

• 1211588-84-9 7-chloro-3-phenyl-1H-pyrazolo[4,3-d]pyrimidine 

Relevant academic research and scientific papers

Novel Substituted Purine Isosteres: Synthesis, Structure-Activity Relationships and Cytotoxic Activity Evaluation

A number of pyrrolo[2,3-c]pyridines, pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines were designed and synthesized as antiproliferative agents. The target compounds possessed selected substituents in analogous positions on the central scaffold th

ISOTHIAZOLOPYRIMIDINONES, PYRAZOLOPYRIMIDINONES, AND PYRROLOPYRIMIDINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.

Synthesis of new series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4-ones for their bacterial and cyclin-dependent kinases (CDKs) inhibitory activities

Two series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4- ones were designed, synthesised, and evaluated for their antibacterial activities and CDKs inhibitory activities. The pyridazine derivative: 6-phenyl-5-phenylhydrazono-2,3,4,5-tetrahydropyridazine- 3,4-dione (3a) revealed activity against Staphylococcus aureus as Gram-positive bacteria while compound 2-(2- Ethoxyphenyl-5-Phenylpiperazinosulfonamido)-3H-pyrido [2,3-d]pyrimidin-4-one (13c) was showing moderate antifungal activity against Candida albicans.