70019-93-1

Upstream product

• 67-56-1 methanol 
• 39687-95-1 isocyanoacetic acid methyl ester 
• 1863-63-4 ammonium benzoate 
• 78-84-2 isobutyraldehyde 
• 72-18-4 L-valine 
• 2901-80-6 N-benzoyl-L-valine 
• 5680-79-5 glycine ethyl ester hydrochloride 

Downstream Products

• 117289-89-1 (2-Benzoylamino-3-methyl-butyrylamino)-bromo-acetic acid methyl ester 
• 117290-08-1 2-(2-Benzoylamino-3-methyl-butyrylamino)-3-ethoxycarbonyl-succinic acid 4-ethyl ester 1-methyl ester 
• 117289-97-1 (2-Benzoylamino-3-methyl-butyrylamino)-methoxy-acetic acid methyl ester 
• 117290-11-6 2-(2-Benzoylamino-3-methyl-butyrylamino)-pent-4-enoic acid methyl ester 
• 34996-83-3 N-benzoyl-valine amide 

Relevant academic research and scientific papers

A potential greener protocol for peptide coupling reactions using recyclable/reusable ionic liquid [ C 4-DABCO ] [ N(CN) 2 ]

Abstract : Development of greener methodologies in synthetic organic chemistry has brought awareness in recent decades due to the ecological performance of green solvent media and catalytic systems. Here, we carried out the peptide bond formation reaction in one of the environmentally secure solvents, ‘ionic liquids’ in the presence of coupling reagent and in the absence of external base at room temperature, affording dipeptides in good to excellent yields. GRAPHICAL ABSTRACT: SYNOPSIS We carried out the peptide bond formation reaction in ionic liquids in the presence of a coupling reagent at room temperature, in the absence of an external base, affording dipeptides in good to excellent yields.

A green protocol for peptide bond formation in WEB

A simple, efficient, and environmentally friendly approach has been developed for the synthesis of peptides in aqueous medium. In this work, peptides are easily synthesized in water extract of banana (WEB)/ethylene glycol and without using external base u

Ammonia in Ugi reactions - Four-component versus six-component couplings

If ammonia is used as amine component in Ugi reactions, the desired peptide sometimes is obtained only as the minor product or in traces. Side reactions such as six-component couplings are responsible for this observation. These side reactions can be suppressed or favoured depending on the reaction conditions used.

Coupling of N-trifluoroacetyl amino acids under 'neutral' conditions.

The possibility of using the trifluoroacetyl group as a base-labile N-protection in peptide synthesis is discussed.Under normal coupling conditions, a very high level of racemization is observed.However, when 'neutral' coupling conditions (by silylation of amino acids or peptides) were used, the coupling racemization decreased as much as 1-2percent. - Key words: peptide coupling; N-protection; N-trifluoroacetyl amino acid; racemization, silylated amino acid