7002-65-5

Usage

InChI:InChI=1/C6H13NO3/c1-7(2,3-4-8)5-6(9)10/h8H,3-5H2,1-2H3

Upstream product

• 3053-29-0 4,4-dimethyl-2-oxomorpholinium chloride 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 79-11-8 chloroacetic acid 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 3053-29-0 4,4-dimethyl-2-oxomorpholinium chloride 

Relevant academic research and scientific papers

Silver nanoparticles with pH induced surface charge switchable properties for antibacterial and antibiofilm applications

Silver nanoparticles (AgNPs) are widely used as antibacterial agents because of their significant antimicrobial activities and little sign of antimicrobial resistance. However, the relatively high toxicity to healthy cells and low penetration efficiency into bacterial biofilms prevent their further use in biomedical applications. In order to decrease the cytotoxicity of the AgNPs to mammalian cells while increasing their antibacterial and antibiofilm efficiency, a novel nanocomposite composed of AgNPs decorated with carboxyl betaine groups (AgNPs-LA-OB) was prepared. The zwitterion modified AgNPs showed a pH responsive transition from a negative charge to a positive charge, which enabled the AgNPs to be compatible with mammalian cells and red blood cells (RBCs) in healthy tissues (pH ～ 7.4), while strongly adhering quickly to negatively charged bacterial surfaces at infectious sites (pH ～ 5.5) based on electrostatic attraction. The AgNPs penetrated deeply into bacterial biofilms and killed the bacteria living in an acidic environment. The results indicated that the designed zwitterion NPs for antibacterial applications and eradication of bacterial biofilms, which also had particles that did not harm the healthy cells showed promise for future use in humans. The satisfactory selectivity for bacteria compared to RBCs, together with their potent eradication of bacterial biofilms make AgNPs-LA-OB a promising antibacterial nanomedicine in biomedical fields.

Mechanistic study on the facilitation of enzymatic hydrolysis by α-glucosidase in the presence of betaine-type metabolite analogs

Recently we reported that betaine-type metabolite analogs structure-dependently facilitate enzymatic hydrolysis reaction for α-glucosidases, β-glucosidases, and alkaliphosphatases. To understand the facilitation mechanism for enzymes, in this study we exp

Formation of 4,4-Dialkyl-2-oxo-morpholinium Chlorides. II

Dialkylaminoethanole 2 reagieren mit Chloracetaten 1 zu den N,N-Dialkyl-2-oxo-morpholinium-salzen 6.Es wird gezeigt, dass die Reaktion zweistufig und ueber die Ester 3-5 verlaeuft, welche zu den Salzen 6 cyclisieren.Das Zwischenprodukt 5a wurde isoliert, seine Struktur aufgeklaert und ein Reaktionsmechanismus vorgeschlagen. 2-Oxo-morpholiniumsalze 6 hydrolysieren in waessriger Loesung zu den entsprechenden Betainen 7.Der Hydrolysegrad wurde bestimmt.Die Betaine 7 koennen in umgekehrter Weise zu den 2-Oxo-morpholinium-Derivaten 6 cyclisieren.