70052-93-6Relevant academic research and scientific papers
Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors
Gahman, Timothy C.,Herbert, Mark R.,Lang, Henk,Thayer, Angie,Symons, Kent T.,Nguyen, Phan Manh,Massari, Mark E.,Dozier, Sara,Zhang, Yan,Sablad, Marciano,Rao, Tadimeti S.,Noble, Stewart A.,Shiau, Andrew K.,Hassig, Christian A.
scheme or table, p. 6888 - 6894 (2011/12/22)
We have identified and synthesized a series of imidazole containing dimerization inhibitors of inducible nitric oxide synthase (iNOS). The necessity of key imidazole and piperonyl functionality was demonstrated and SAR studies led to the identification of compound 35, which showed a dose dependant inhibition in multiple pain models, including tactile allodynia induced by spinal nerve ligation (Chung model).
Mechanistic considerations for the consecutive cyclization of 2,3-dibromopropylamine hydrobromide giving a strained molecule, 1-azabicyclo[1.1.0]butane
Hayashi, Kazuhiko,Ikee, Yoshifumi,Goto, Satoru,Shiro, Motoo,Nagao, Yoshimitsu
, p. 89 - 94 (2007/10/03)
The effective formation of 1-azabicyclo[1.1.0]butane (2) by treatment of 2,3-dibromopropylamine hydrobromide (1) with n-BuLi could be understood considering a rational reaction pathway via both transition states 10 and 19 based on the intramolecular Br...
Preparation of Azetidines from 1,3-Aminopropanols
Sammes, Peter G.,Smith, Steven
, p. 2415 - 2420 (2007/10/02)
The preparation of 1,3-amino alcohols by the reduction of azetidin-2-ones with diborane is described.New methods for the cyclisation of the aminopropanols to the corresponding azetidines are reported; these methods centre on the use of a modified Mitsunobu reaction.
On the Synthesis of Azetidines from 3-Hydroxypropylamines
Sammes, Peter G.,Smith, Steven
, p. 682 - 684 (2007/10/02)
New methods are described for preparing azetidines from 3-hydroxypropylamines involving the use of triphenylphosphine and diethyl azodicarboxylate and related reagents.
