701-39-3

Basic information

• Product Name: N-Methyl3-fuorobenzamide
• Synonyms: N-Methyl3-fuorobenzamide;3-Fluoro-N-methylbenzamide
• CAS NO: 701-39-3
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.15
• Mol File: 701-39-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Methyl3-fuorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl3-fuorobenzamide(701-39-3)
• EPA Substance Registry System: N-Methyl3-fuorobenzamide(701-39-3)

Safety Data

• Hazardous Substances Data: 701-39-3(Hazardous Substances Data)

Usage

General Description

N-Methyl-3-fluorobenzamide is an organic compound with the chemical formula C8H8FNO. It is a derivative of benzamide and is commonly used in organic synthesis as a building block for various pharmaceuticals and agrochemicals. N-Methyl-3-fluorobenzamide is a white crystalline solid with a melting point of 73-75°C and is soluble in a variety of solvents such as methanol, ethanol, and acetone. It is also used in the production of dyes and pigments, as well as in the manufacturing of polymers and plastics. N-Methyl-3-fluorobenzamide is known to have moderate acute toxicity and may cause irritation to the skin, eyes, and respiratory system upon exposure.

Upstream product

• 455-38-9 3-fluorobenzoic acid 
• 593-51-1 methylamine hydrochloride 
• 1711-07-5 3-fluorobenzoyl chloride 
• 455-68-5 methyl 3-fluorobenzoate 
• 74-89-5 methylamine 
• 67-56-1 methanol 
• 455-37-8 3-fluorobenzamide 
• 90389-84-7 1-(3-fluorophenyl)-N-methylmethanamine 

Downstream Products

• 1315257-24-9 5-fluoro-2-methyl-3,4-diphenylisoquinolin-1(2H)-one 
• 1315257-23-8 7-fluoro-2-methyl-3,4-diphenylisoquinolin-1(2H)-one 
• 1355020-72-2 (E)-ethyl 3-{2-fluoro-6-(methylcarbamoyl)phenyl}acrylate 

Relevant articles and documents

Iridium-catalyzed, ligand-controlled directed alkynylation and alkenylation of arenes with terminal alkynes

We report iridium-catalyzed C-C formation between benzamides and terminal alkynes. With the choice of a suitable ligand, a C-H alkynylation or alkenylation product could be obtained selectively. The directed C-H alkynylation proceeded without the need for an external oxidant, while the directed C-H alkenylation likely involves an unusual vinylidene mechanism. This divergent reactivity provides access to both alkynylation and alkenylation products from the same set of starting materials.

Ruthenium-Catalyzed Synthesis of N-Methylated Amides using Methanol

An efficient synthesis of N-methylated amides using methanol in the presence of a ruthenium(II) catalyst is realized. Notably, applying this process, tandem C-methylation and N-methylation were achieved to synthesize α-methyl N-methylated amides. In addition, several kinetic studies and control experiments with the plausible intermediates were performed to understand this novel protocol. Furthermore, detailed computational studies were carried out to understand the mechanism of this transformation.

I2-Catalyzed Oxidative Amidation of Benzylamines and Benzyl Cyanides under Mild Conditions

We report a novel and efficient method for the oxidation of benzylic carbons (amines and cyanides) into corresponding benzamides using a catalytic amount of I2 and TBHP as the green oxidant via the C-H bond cleavage of the benzylic carbon under mild reaction conditions. According to the literature survey, this is the first report for the oxidative amidation of benzylamines and decyanation of benzyl cyanides in one pot under metal-free conditions.