70132-50-2 Usage
Uses
Used in Hypoxia Detection:
Pimonidazole is used as a hypoxia detection reagent for identifying hypoxic cells in tumors. It forms adducts with thiol groups in proteins, peptides, and amino acids, effectively labeling hypoxic tumor cells in vivo.
Used in Cancer Research:
Pimonidazole is used as a marker for hypoxic cells in various types of cancer, including human squamous cell carcinomas of the cervix, head, and neck. Its ability to label hypoxic cells makes it a valuable tool in understanding the behavior of these cells and their resistance to radiotherapy and chemotherapy.
Used in Stem Cell Research:
Pimonidazole is used as a marker for hypoxic mesenchymal stem cells in mouse bone marrow. This application aids in the study of stem cell behavior and their potential role in tissue regeneration and repair under hypoxic conditions.
Used in Radiotherapy and Chemotherapy:
Pimonidazole is used as a radiosensitizer to enhance the effectiveness of radiotherapy and chemotherapy in treating tumors with hypoxic cells. By increasing the sensitivity of these cells to treatment, Pimonidazole can improve the overall outcome of cancer treatment.
Used in Pharmaceutical Development:
Pimonidazole is used as a starting point for the development of new drugs targeting hypoxia in tumors. Its properties as a hypoxia marker and radiosensitizer make it a promising candidate for the creation of novel therapeutic agents.
Biochem/physiol Actions
Pimonidazole is an effective and nontoxic exogenous 2-nitroimidazole hypoxia marker. Pimonidazole forms adducts with thiol groups in proteins, peptides and amino acids.
Check Digit Verification of cas no
The CAS Registry Mumber 70132-50-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,1,3 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 70132-50:
(7*7)+(6*0)+(5*1)+(4*3)+(3*2)+(2*5)+(1*0)=82
82 % 10 = 2
So 70132-50-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H18N4O3/c16-10(8-13-5-2-1-3-6-13)9-14-7-4-12-11(14)15(17)18/h4,7,10,16H,1-3,5-6,8-9H2
70132-50-2Relevant academic research and scientific papers
Nitroimidazoles and compositions thereof
-
, (2008/06/13)
Nitroimidazoles of the formula STR1 wherein R1 and R2 are as hereinafter set forth, are described. The nitroimidazoles are useful as hypoxic-cell radiosensitizers, as well as being useful as antiprotozoal agents.
