70163-98-3

Basic information

• Product Name: 3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER
• Synonyms: RARECHEM AL BF 0031;3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER;Methyl 3-fluorosalicylate;3-Fluorosalicylic acid methyl ester
• CAS NO: 70163-98-3
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.14
• Product Categories: pharmacetical;Benzoic acid
• Mol File: 70163-98-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 46-47 °C
• Boiling Point: 211.7 °C at 760 mmHg
• Flash Point: 81.8 °C
• Appearance: /
• Density: 1.309 g/cm³
• Vapor Pressure: 0.124mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.50±0.10(Predicted)
• CAS DataBase Reference: 3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER(70163-98-3)
• EPA Substance Registry System: 3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER(70163-98-3)

Safety Data

• Hazardous Substances Data: 70163-98-3(Hazardous Substances Data)

Usage

General Description

3-Fluoro-2-hydroxy-benzoic acid methyl ester is a chemical compound with the molecular formula C8H7FO3. It is a methyl ester derivative of 3-fluoro-2-hydroxybenzoic acid, with the fluorine atom and hydroxyl group located on the benzene ring. 3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active molecules. It may also have potential applications in the development of new drugs or agrochemicals. 3-Fluoro-2-hydroxy-benzoic acid methyl ester is a white to off-white crystalline solid with a melting point of around 118-120°C, and should be handled and stored with appropriate safety precautions due to its potential hazards.

InChI:InChI=1/C8H7FO3/c1-12-8(11)5-3-2-4-6(9)7(5)10/h2-4,10H,1H3

Upstream product

• 455-68-5 methyl 3-fluorobenzoate 
• 367-12-4 2-fluorophenol 
• 67-56-1 methanol 
• 854914-89-9 3-fluoro-2-hydroxy-thiobenzoic acid S-methyl ester 
• 119-36-8 methyl salicylate 
• 341-27-5 3-fluorosalicylic acid 

Downstream Products

• 934753-37-4 methyl 5-fluoro-2-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]benzoate 
• 177348-35-5 C₇H₆FNO₃ 
• 705949-54-8 3-fluoro-2-hydroxybenzamide 
• 70163-99-4 N-(2-diethylaminoethyl)-3-fluorosalicylamide hydrochloride 

Relevant articles and documents

Rhodium(III)-Catalyzed Oxidative Intramolecular 1,1-Oxyamination of Alkenes with Protected Amino Acids to Produce Oxazoloisoindole-2,5-diones

It has been established that an electron-deficient bis(ethoxycarbonyl)-substituted cyclopentadienyl (CpE) rhodium(III) complex catalyzes the oxidative intramolecular 1,1-oxyamination of alkenes with N-benzoyl amino acids to produce oxazoloisoindole-2,5-diones. Experimental and theoretical mechanistic studies revealed that this oxidative 1,1-oxyamination proceeds via not the aza-Wacker reaction but the formation of a rhoda(III)oxazolidine initiated by the carboxylic acid-directed N?H bond cleavage.

CALCILYTIC COMPOUNDS

Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

A short and efficient preparation of methyl-[1,2,4]oxadiazolium derivatives with plant-inducing activity

A short and efficient preparation of methyl-[1,2,4]oxadiazolium derivatives with plant-inducing activity is discussed. A concise and efficient synthetic method leading to structurally diverse array of oxadiazolium derivatives, starting from halogenated phenols is also developed. The starting point of the synthesis is the Lewis acid mediated addition of isocyanates to phenols. The strategy also involves a new and rapid access to all meta-halogenated salicylic acids, compounds of high synthetic value.