701910-14-7

Basic information

• Product Name: 7-BROMO-2-METHYL-2H-INDAZOLE
• Synonyms: 7-BROMO-2-METHYL-2H-INDAZOLE;7-Bromo-2-methylindazole
• CAS NO: 701910-14-7
• Molecular Formula: C₈H₇BrN₂
• Molecular Weight: 211.06
• Product Categories: Indazole;Organohalides
• Mol File: 701910-14-7.mol

Chemical Properties

• Boiling Point: 322.7 °C at 760 mmHg
• Flash Point: 148.9 °C
• Appearance: /
• Density: 1.6 g/cm³
• Refractive Index: 1.663
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-BROMO-2-METHYL-2H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMO-2-METHYL-2H-INDAZOLE(701910-14-7)
• EPA Substance Registry System: 7-BROMO-2-METHYL-2H-INDAZOLE(701910-14-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 701910-14-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
7-BROMO-2-METHYL-2H-INDAZOLE is used as a building block for the synthesis of biologically active compounds, contributing to the development of new drugs. Its diverse reactivity allows for the creation of chemical entities with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 7-BROMO-2-METHYL-2H-INDAZOLE is utilized as a key component for the creation of novel chemical entities, facilitating the development of new compounds with various applications.
Used in Agrochemical Development:
7-BROMO-2-METHYL-2H-INDAZOLE is employed as a key component in the development of novel agrochemicals, where its unique properties and structure contribute to the creation of new products with potential applications in agriculture.
Used in Functional Materials:
7-BROMO-2-METHYL-2H-INDAZOLE is also used in the development of functional materials, where its properties and structure are leveraged to create materials with specific characteristics for various industrial applications.

InChI:InChI=1/C8H7BrN2/c1-11-5-6-3-2-4-7(9)8(6)10-11/h2-5H,1H3

Upstream product

• 77-78-1 dimethyl sulfate 
• 53857-58-2 7-bromo-1H-indazole 
• 845751-59-9 7-bromo-2H-indazole 
• 74-88-4 methyl iodide 
• 845751-60-2 (2-bromo-6-methylphenyl)[(1,1-dimethylethyl)thio]diazene 
• 53848-17-2 2-bromo-6-methylaniline 

Downstream Products

• 845751-70-4 7-Bromo-2-methyl-2H-indazole-3-carbaldehyde 
• 701910-15-8 7-(2,4-dichloro-phenyl)-2-methyl-2H-indazole 
• 845751-62-4 7-bromo-2,3-dimethyl-2H-indazole 
• 845751-91-9 C₁₅H₁₃BrN₂S 
• 845751-90-8 C₂₀H₂₀Cl₂N₄O₂ 
• 845751-92-0 C₈H₆BrClN₂O₂S 
• 845751-85-1 N-[7-(2,4-dichloro-phenyl)-2-methyl-2H-indazol-3-ylmethyl]-N-methyl-acetamide 

Relevant articles and documents

METHODS OF TREATING LIVER FIBROSIS USING CALPAIN INHIBITORS

Disclosed herein are methods of treating liver fibrosis by administering calpain inhibitors to subjects in need thereof.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Small molecule calpain modulator compounds, including their pharmaceutically acceptable salts, can be included in pharmaceutical compositions. The compounds can be useful in inhibiting calpain, or competitive binding with calpastatin, by contacting them with CAPN1, CAPN2, and/or CAPN9 enzymes residing inside a subject. The compounds and composition can also be administered to a subject in order to treat a fibrotic disease or a secondary disease state or condition of a fibrotic disease.

Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators

The design and the synthesis of several chemical subclasses of imidazole containing γ-secretase modulators (GSMs) is described. Conformational restriction of pyridone 4 into bicyclic pyridone isosteres has led to compounds with high in vitro and in vivo p

NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS

Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS

Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension

NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS

Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK- activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

GABANERGIC MODULATORS

This invention relates to the use of compounds of benzoindazole derivatives salts and solvates thereof for the preparation of a medicament for modulating alpha2 subtype GABA A receptors. The invention further relates to novel heterocyclic compounds and pharmaceutical compositions containing said compounds. In addition the invention relates to the use of compounds of formula (I) salts and solvates thereof for the preparation of a medicament for the treatment of depression, an anxiety disorder, a psychiatric disorder, a learning or cognitive disorder, a sleep disorder, a convulsive or seizure disorder or pain.

Indazole derivatives as CRF antagonists

This invention relates to compounds which are generally CRF-1 receptor antagonists and which are represented by Formula I or Formula II: wherein R3 is optionally substituted aryl or heteroaryl, R1 and R2 are as defined in