845751-60-2

Upstream product

• 53848-17-2 2-bromo-6-methylaniline 
• 75-66-1 2-methylpropan-2-thiol 
• 601-87-6 3-methyl-2-nitroaniline 
• 52414-97-8 1-bromo-3-methyl-2-nitro-benzene 

Downstream Products

• 845751-59-9 7-bromo-2H-indazole 
• 53857-58-2 7-bromo-1H-indazole 
• 701910-14-7 7-bromo-2-methyl-2H-indazole 
• 701910-15-8 7-(2,4-dichloro-phenyl)-2-methyl-2H-indazole 
• 701910-21-6 7-(2,4-dichloro-phenyl)-2-methyl-2H-indazol-3-ylamine 
• 845751-92-0 C₈H₆BrClN₂O₂S 
• 845751-61-3 7-(2,4-dichloro-phenyl)-1H-indazole 

Relevant academic research and scientific papers

Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators

The design and the synthesis of several chemical subclasses of imidazole containing γ-secretase modulators (GSMs) is described. Conformational restriction of pyridone 4 into bicyclic pyridone isosteres has led to compounds with high in vitro and in vivo p

NOVEL SUBSTITUTED INDAZOLE AND AZA-INDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted indazole and aza-indazole derivatives of Formula (I), wherein R1, R2, R3, R4, Y, A1, A2, A3, A4, X1, X2, X3 and Het1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

GABANERGIC MODULATORS

This invention relates to the use of compounds of benzoindazole derivatives salts and solvates thereof for the preparation of a medicament for modulating alpha2 subtype GABA A receptors. The invention further relates to novel heterocyclic compounds and pharmaceutical compositions containing said compounds. In addition the invention relates to the use of compounds of formula (I) salts and solvates thereof for the preparation of a medicament for the treatment of depression, an anxiety disorder, a psychiatric disorder, a learning or cognitive disorder, a sleep disorder, a convulsive or seizure disorder or pain.

Indazole derivatives as CRF antagonists

This invention relates to compounds which are generally CRF-1 receptor antagonists and which are represented by Formula I or Formula II: wherein R3 is optionally substituted aryl or heteroaryl, R1 and R2 are as defined in