70199-99-4Relevant academic research and scientific papers
Enantioselective Palladium-Catalyzed Oxidative β,β-Fluoroarylation of α,β-Unsaturated Carbonyl Derivatives
Miró, Javier,del Pozo, Carlos,Toste, F. Dean,Fustero, Santos
, p. 9045 - 9049 (2016)
The site-selective palladium-catalyzed three-component coupling of deactivated alkenes, arylboronic acids, and N-fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step-economical approach to the stereoselective β-fluorination of α,β-unsaturated systems.
Silver-Catalyzed Decarboxylative Alkylfluorination of Alkenes
Li, Chen-Guang,Xie, Qiang,Xu, Xiao-Lan,Wang, Feng,Huang, Bei,Liang, Yu-Feng,Xu, Hua-Jian
supporting information, p. 8496 - 8500 (2019/10/14)
A decarboxylation of alkyl carboxylic acids for alkylfluorination of alkene was developed, with the catalysis of silver(I) and Selectfluor as both the oxidant and fluorine source. This reaction is highly chemoselective, producing the decarboxylative alkyl
A metal-free and regioselective approach to (Z)-β-fluorovinyl sulfones and their chemoselective hydrogenation to β-fluoroalkyl sulfones
Sedgwick, Daniel M.,Román, Raquel,Barrio, Pablo,Morales, Cristina,Fustero, Santos
, p. 108 - 116 (2018/01/01)
A highly regioselective, metal-free hydrofluorination reaction of alkynyl sulfones was developed using TBAF—one of the cheapest and most commonly available fluoride sources. In addition, the reactivity of the resulting β-fluorovinyl sulfones was studied, focusing on their selective hydrogenation reaction. Both β-fluorovinyl sulfones and their hydrogenation products β-fluoroalkyl sulfones may find applications in medicinal and agrochemical sciences.
A continuous-flow protocol for light-induced benzylic fluorinations
Cantillo, David,De Frutos, Oscar,Rincón, Juan A.,Mateos, Carlos,Kappe, C. Oliver
, p. 8486 - 8490 (2015/03/18)
A continuous-flow protocol for the light-induced fluorination of benzylic compounds is presented. The procedure uses Selectfluor as the fluorine source and xanthone as an inexpensive and commercially available photoorganocatalyst. The flow photoreactor is based on transparent fluorinated ethylene propylene tubing and a household compact fluorescent lamp. The combination of xanthone with black-light irradiation results in very efficient fluorination. Good to excellent isolated yields were obtained for a variety of substrates bearing different functional groups applying residence times below 30 min.
FLUORINATION OF HYDROXYESTERS WITH N,N-DIETHYL-1,1,2,3,3,3-HEXAFLUOROPROPYLAMINE
Watanabe, S.,Fujita, T.,Usui, Y.,Kitazume, T.
, p. 247 - 254 (2007/10/02)
The reaction of 1,1,2,3,3,3-hexafluoropropyldiethylamine (PPDA) with hydroxy esters having Ph-C(H)(OH)-groups gave their corresponding secondary fluorides.Fluorination of (R)-(-)-mandelic acid ethylester (29D -106.46) gave ethyl (
Conformational Studies on 2-Fluoro-1,2-disubstituted Ethanes by NMR Spectroscopy. Influence of Electronegativity on Vicinal Proton-Proton and Fluorine-Proton Coupling Constants
Hamman, Sylvain,Beguin, Claude,Charlon, Claude,Luu-Duc, Cuong
, p. 361 - 366 (2007/10/02)
The analysis of the ABKX spectra of thirteen compounds of the series RC(H-K)(F-X)C(H-A)(H-B)X gave the four vicinal proton-proton and fluorine-proton coupling constants.These coupling constants of conformationally mobile structures were used (i) to calcul
EFFET DE LA CONCENTRATION EN ACIDE FLUORHYDRIQUES DANS LA PYRIDINE SUR LA REGIO-SELECTITE DE LA FLUORATION PAR DEAMINATION D'α-AMINO-ESTERS : SYNTHESES DE COMPOSES CARBOXYLES-β-FLUORES.
Hamman, Sylvain,Beguin, Claude G.
, p. 57 - 60 (2007/10/02)
Fluorodeamination of α-amino-esters with sodium nitrite in HF-pyridine gives mainly β-fluoro-esters.The molar ratio HF-pyridine is the main parameter for the α-β regioselectivity.
