70209-54-0Relevant articles and documents
CHEMICAL SYNTHESIS OF THE HUMAN BLOOD-GROUP P1-ANTIGENIC DETERMINANT-
Amvam Zollo, Paul-Henri,Jacquinet, Jean-Claude,Sinay, Pierre
, p. 201 - 208 (2007/10/02)
Condensation of known benzyl 2-acetamido-3,6-di-O-benzyl-2-deoxy-4-O-(2,3,6-tri-O-benzyl-β-D-galactopyranosyl)-α-D-glucopyranoside with 2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl chloride in dichlormethane in the presence of 2,4,6-trimethylpyridine, silv
Bausteine von Oligosacchariden, XX. Synthese der Oligosaccharid-Determinanten der Blutgruppensubstanzen der Type 2 des ABH-Systems. Diskussion der &α-Glycosid-Synthese
Paulsen, Hans,Kolar, Cenek
, p. 306 - 321 (2007/10/02)
The antigenic determinants of type 2 of blood-group substances A and B (23 and 24) as well as blood-group substance H (17) were synthesized by selective glycosidation reactions combined with a series of blocking and deblocking steps.The possibilities and optimization of the α-glycoside synthesis are discussed.In hemagglutination inhibition tests the synthetic haptens A and B of type 2 and type 1 show a similar selective inhibitory effect.In case of hapten H, however, great differences can be observed.Here the type 2 exhibited a strong inhibition activity, whereas type 1 only showed an extremly low activity.This leads to the conclusion that in the determinants of the ABH-system on the surface of erythrocytes the chemical structure of type 2 is predominating.