702701-70-0

Basic information

• Product Name: methanesulfonic acid 2-[2-(2-benzyloxy-ethoxy)-ethoxy]-ethyl ester
• Synonyms: methanesulfonic acid 2-[2-(2-benzyloxy-ethoxy)-ethoxy]-ethyl ester
• CAS NO: 702701-70-0
• Molecular Weight: 318.391
• Mol File: 702701-70-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: methanesulfonic acid 2-[2-(2-benzyloxy-ethoxy)-ethoxy]-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methanesulfonic acid 2-[2-(2-benzyloxy-ethoxy)-ethoxy]-ethyl ester(702701-70-0)
• EPA Substance Registry System: methanesulfonic acid 2-[2-(2-benzyloxy-ethoxy)-ethoxy]-ethyl ester(702701-70-0)

Safety Data

• Hazardous Substances Data: 702701-70-0(Hazardous Substances Data)

Upstream product

• 55489-58-2 triethylene glycol monobenzyl ether 
• 124-63-0 methanesulfonyl chloride 
• 96042-30-7 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 100-39-0 benzyl bromide 

Downstream Products

• 1003598-44-4 2-{2-[2-(3,3,3-trifluoro-propoxy)-ethoxy]-ethoxy}-ethoxymethyl-benzene 
• 1003598-45-5 2-{2-[2-(4,4,4-trifluoro-butoxy)-ethoxy]-ethoxy}-ethoxymethyl-benzene 
• 86770-75-4 2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethan-1-amine 
• 86770-70-9 ((2-(2-(2-azidoethoxy)ethoxy)ethoxy)methyl)benzene 
• 1273387-07-7 {2-[2-(2-hydroxyethoxy)ethoxy]ethyl} (6-{(pyridin-2-ylsulfonyl)[4-(thiazol-2-yl)benzyl]aminomethyl}pyridin-2-ylamino)acetate 
• 1273387-06-6 2-{2-[2-(benzyloxy)ethoxy]ethoxy}ethyl 2-({6-[(N-{[4-(1,3-thiazol-2-yl)phenyl]methyl}pyridine-2-sulfonamido)methyl]pyridin-2-yl}amino)acetate 
• 423763-19-3 monobenzyl heptaethylene glycol 

Relevant articles and documents

HETEROCYCLIC COMPOUND

It is to provide a novel heterocyclic compound which has the effect of inducing degradation of interleukin-1 receptor-associated kinase-M (IRAK-M) protein and is expected to be useful for the prevention/treatment of cancer, fibrosis, infectious diseases, etc. The present invention provides a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof.

Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands

Proteolysis targeting chimeras (PROTACs) hijacking the cereblon (CRBN) E3 ubiquitin ligase have emerged as a novel paradigm in drug development. Herein we found that linker attachment points of CRBN ligands highly affect their aqueous stability and neosubstrate degradation features. This work provides a blueprint for the assembly of future heterodimeric CRBN-based degraders with tailored properties.

Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof

Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.