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Usage

Uses

Used in Cosmetic and Personal Care Industry:
2-(4-CHLORO-3-METHYLPHENOXY)-ETHANOL is used as a preservative for its antimicrobial properties, ensuring the prevention of bacterial and fungal growth in various cosmetic and personal care products. This helps maintain product integrity and safety for consumers, extending the shelf life of these products while protecting them from microbial contamination.
However, due to the potential health concerns associated with its use, such as skin irritation and allergic reactions, it is crucial to employ this chemical within the limits of safety standards and guidelines. This includes conducting thorough safety assessments and ensuring that the concentration of 2-(4-CHLORO-3-METHYLPHENOXY)-ETHANOL in products is kept to a minimum necessary to achieve the desired preservative effect, thereby balancing efficacy and safety.

InChI:InChI=1/C9H11ClO2/c1-7-6-8(12-5-4-11)2-3-9(7)10/h2-3,6,11H,4-5H2,1H3

Upstream product

• 588-20-5 4-chloro-3-methylphenoxyacetic acid 
• 59-50-7 4-Chloro-3-methylphenol 
• 540-51-2 2-bromoethanol 
• 107-07-3 2-chloro-ethanol 

Relevant academic research and scientific papers

Synthesis, anticonvulsant activity and metabolism of 4-chlor-3-methylphenoxyethylamine derivatives of trans-2-aminocyclohexan-1-ol

In this study, we report the synthesis, spectral characterization, antiepileptic activity and biotransformation of three new, chiral, N-aminoalkyl derivatives of trans - 2 aminocyclohexan-1-ol: 1 (R enantiomer), 2 (S enantiomer) and 3 (racemate). Antiepileptic activity of the titled compounds was studied using MES and scMet. Moreover, in this study, the biotransformation of 1, 2 and 3 in microbial model (Cunninghamella), liver microsomal assay as well as in silico studies (MetaSite) was evaluated. Studies have indicated that 1, 2 and 3 have good antiepileptic activity in vivo, comparable to valproate. Biotransformation assays showed that the most probable metabolite (indicated in every tested assays) was M1. The microbial model as well as in silico study showed no difference in biotransformation between tested enantiomers. However, in a rat liver microsomal study compound 1 and 2 (R and S enantiomer) had different main metabolite - M2 for 1 and M1 for 2. MS/MS fragmentation allowed us to predict the structures of obtained metabolites, which were in agreement with 1°alcohol (M1) and carboxylic acid (M2). Our research has shown that microbial model, microsomal assay, and computational methods can be included as useful and reliable tools in early ADME-Tox assays in the process of developing new drug candidates.