588-20-5

Basic information

• Product Name: (4-CHLORO-3-METHYL-PHENOXY)-ACETIC ACID
• Synonyms: (4-chloro-3-methylphenoxy)acetic acid(SALTDATA: FREE);2-(4-chloro-3-methyl-phenoxy)ethanoic acid;Acetic acid, ((4-chloro-m-tolyl)oxy)-;Acetic acid, (4-chloro-3-methylphenoxy)-
• CAS NO: 588-20-5
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.62
• Mol File: 588-20-5.mol
• Article Data: 18

Chemical Properties

• Melting Point: 176 °C(Solv: water (7732-18-5))
• Boiling Point: 334.7°Cat760mmHg
• Flash Point: 156.2°C
• Appearance: /
• Density: 1.313g/cm³
• Vapor Pressure: 4.95E-05mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: 2-8°C
• PKA: 3.10±0.10(Predicted)
• CAS DataBase Reference: (4-CHLORO-3-METHYL-PHENOXY)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLORO-3-METHYL-PHENOXY)-ACETIC ACID(588-20-5)
• EPA Substance Registry System: (4-CHLORO-3-METHYL-PHENOXY)-ACETIC ACID(588-20-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 588-20-5(Hazardous Substances Data)

Usage

General Description

(4-CHLORO-3-METHYL-PHENOXY)-ACETIC ACID is a chemical compound that falls under the class of phenoxyalkanoic acids. It is a derivative of acetic acid and is characterized by the presence of a chloro and methyl group in the phenyl ring. (4-CHLORO-3-METHYL-PHENOXY)-ACETIC ACID is commonly used as a herbicide, specifically as a post-emergence broadleaf herbicide for controlling various types of weeds in agricultural settings. It works by disrupting the growth of weeds and inhibiting their ability to compete with crops for nutrients and resources. Additionally, it can also be used as a plant growth regulator to promote root and shoot growth in certain crops. As with all chemical compounds, proper handling and storage are essential to ensure the safety of those using it.

InChI:InChI=1/C9H9ClO3/c1-6-4-7(2-3-8(6)10)13-5-9(11)12/h2-4H,5H2,1H3,(H,11,12)

Upstream product

• 59-50-7 4-Chloro-3-methylphenol 
• 79-08-3 bromoacetic acid 
• 108-39-4 3-methyl-phenol 
• 30406-61-2 ethyl 2-(4-chloro-3-methylphenoxy)acetate 
• 105-36-2 ethyl bromoacetate 
• 1643-15-8 2-(m-tolyloxy)acetic acid 
• 79-11-8 chloroacetic acid 

Downstream Products

• 345933-90-6 (4-Chloro-3-methyl-phenoxy)-acetic acid 2-acetyl-6-methyl-phenyl ester 
• 78613-20-4 2-Amino-5-(4'-chloro-3'-methylphenoxymethyl)-1,3,4-oxadiazole 
• 1009733-95-2 C₂₅H₁₅Cl₃FN₃O₂ 
• 1009733-89-4 C₁₆H₁₀Cl₃FN₂O₂ 
• 1063737-90-5 C₁₁H₁₂ClNO₂ 
• 1107604-00-1 C₂₅H₃₆ClNO₅ 
• 1107604-01-2 C₂₅H₃₆ClNO₅ 
• 1252594-21-0 2-(1,3-benzothiazol-2-ylsulfanyl)-N-{5-[(4-chloro-3-methylphenoxy)methyl]-1,3,4-thiadiazol-2-yl}acetamide 
• 84138-78-3 5-[(4-chloro-3-methylphenoxy)methyl]-1,3,4-thiadiazol-2-amine 
• 1252593-99-9 2-{(benzo[d]thiazol-2-ylthio)methyl}-5-(4-chloro-3-methylphenyloxymethyl)-1,3,4-oxadiazole 
• 904702-54-1 O,O-dimethyl α-(3-methyl-4-chlorophenoxyacetoxy)-3-nitrobenzylphosphonate 

Relevant articles and documents

MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra2, Ra4, R

The Novel 4-Phenyl-2-Phenoxyacetamide Thiazoles modulates the tumor hypoxia leading to the crackdown of neoangiogenesis and evoking the cell death

Tumor microenvironment is a complex multistep event which involves several hallmarks that transform the normal cell into cancerous cell. Designing the novel antagonistic molecule to reverse the tumor microenvironment with specific target is essential in modern biological studies. The novel 4-phenyl-2-phenoxyacetamide thiazole analogues 8a-ab were synthesized in multistep process, then screened and assessed for cytotoxic and anti-proliferative effects in vitro against multiple cancer cells of different origin such as MCF-7, A549, EAC and DLA cells which revealed that compound 8f with fluoro and methyl substitute has potential cytotoxic efficacy with an average IC50 value of ? 13 μM. The mechanism of cytotoxicity assessed for anti-tumor studies both in ascites and solid tumor models in-vivo inferred the regressed tumor activity. This is due to changes in the cause of tumor microenvironment with crackdown of neovascularization and evoking apoptosis process as assessed by CAM, corneal vascularization and apoptotic hallmarks in 8f treated cells. The molecular gene studies inferred involvement of HIF-1upregulation and stabilization of p53 which are interlinked in signaling as conferred by immunoblot analysis.

Synthesis and Biological Activity of Ethyl 4-Alkyl-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylate

(Chemical Equation Presented) A series of novel ethyl 4-(methyl or trifluoromethyl)-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylates 7a, 7b, 7c, 7d, 7e and 8f, 8g, 8h, 8i, 8j, 8k, 8l, 8m, 8n, 8o, 8p, 8q, 8r were synthesized, and their structures were confirmed by IR, 1H-NMR, MS spectra and elemental analysis. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal activities. Compared with the fluorine free compounds 7a, 7b, and 7e, the compounds bearing fluorine 8g, 8j, and 8q showed higher herbicidal activities with 70-100% inhibition against Capsella bursa-pastoris, Amaranthus restroflexus, and Eclipta prostrata at the dosage of 150 g/ha, which indicated that the trifluoromethyl on the thiazole ring was beneficial for the herbicidal activity. Furthermore, compounds 8f, 8g, 8h, 8i, 8j, 8k, 8l, 8m, 8n, 8o, 8p, 8q, 8r were tested for fungicidal activity against Pseudoperonospora cubensis at 500 μg/mL. Compounds 8f and 8q showed the best fungicidal activity with more than 80% inhibition.