70525-40-5

Usage

Uses

Used in Coordination Chemistry:
2-(cyclohexylidenemethyl)pyridine is used as a ligand for the formation of coordination compounds. Its unique structure allows it to chelate with metal ions, facilitating the creation of stable complexes that are valuable in various chemical and catalytic processes.
Used in Organic Synthesis:
In the realm of organic synthesis, 2-(cyclohexylidenemethyl)pyridine is utilized as a building block. Its presence in the synthesis of complex organic molecules contributes to the development of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Research:
2-(cyclohexylidenemethyl)pyridine is studied as a potential anti-cancer agent, where it may exhibit properties that could be harnessed to combat cancer cells. Its structure and reactivity are being investigated for their potential to interact with biological targets relevant to cancer treatment.
Used in Neurodegenerative Disease Treatment:
CMP is also being explored for its potential as a treatment for neurodegenerative diseases. Its chemical properties may allow it to modulate pathways or targets implicated in the progression of such diseases, offering a new avenue for therapeutic intervention.
Used in the Chemical Industry:
2-(cyclohexylidenemethyl)pyridine is employed across various sectors of the chemical industry, serving as an intermediate in the production of specialty chemicals, fine chemicals, and other high-value products that require its unique structural attributes.

Upstream product

• 57756-06-6 2-(cyclohexylmethyl)pyridine 
• 109-06-8 α-picoline 
• 626-62-0 Cyclohexyl iodide 
• 1121-60-4 pyridine-2-carbaldehyde 
• 7333-51-9 cyclohexyl(triphenyl)phosphonium bromide 

Relevant academic research and scientific papers

Transition metal-catalyzed intramolecular C-H/olefin coupling

The ruthenium-and rhodium-catalyzed intramolecular C-H/olefin coupling reactions of 1-(2-pyridyl)-1,5-and 1,6-dienes proceeded regio-and stereoselecively to give 5-or 6-membered ring products.

Role of Benzylic Deprotonation in Nickel-Catalyzed Benzylic Dehydrogenation

Alkylarenes are readily functionalized via the corresponding benzylic anions. Benzylic anions have been used for a range of catalytic reactions, including Ni-catalyzed dehydrogenation. Interestingly, the employment of Zn(TMP) 2for slow and incomplete deprotonation of the benzylic position was observed. This manuscript describes a preliminary investigation into the deprotonation of heteroarenes and its relationship to Ni-catalyzed benzylic dehydrogenation.

Aryl-Nickel-Catalyzed Benzylic Dehydrogenation of Electron-Deficient Heteroarenes

This manuscript describes the first practical benzylic dehydrogenation of electron-deficient heteroarenes, including pyridines, pyrazines, pyrimidines, pyridazines, and triazines. This transformation allows for the efficient benzylic oxidation of heteroarenes to afford heterocyclic styrenes by the action of nickel catalysis paired with an unconventional bromothiophene oxidant.

Borane-Catalyzed Chemoselective and Enantioselective Reduction of 2-Vinyl-Substituted Pyridines

Herein, we report that highly chemoselective and enantioselective reduction of 2-vinyl-substituted pyridines has been achieved for the first time. The reaction, which uses chiral spiro-bicyclic bisboranes as catalysts and HBpin and an acidic amide as reducing reagents, proceeds through a cascade process involving 1,4-hydroboration followed by transfer hydrogenation of a dihydropyridine intermediate. The retained double bond in the reduction products permits their conversion to natural products and other useful heterocyclic compounds by simple transformations.