70550-08-2

Upstream product

• 17796-82-6 N-(cyclohexylthio)-phthalimide 
• 1569-69-3 Cyclohexanethiol 
• 868-85-9 Dimethyl phosphite 
• 1112-38-5 O,O-dimethyl S-hydrogen phosphorothioate 
• 126812-30-4 1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate 
• 98-89-5 Cyclohexanecarboxylic acid 

Relevant academic research and scientific papers

Photoinduced Decarboxylative Phosphorothiolation of N-Hydroxyphthalimide Esters

A visible-light-induced protocol for the synthesis of phosphorothioates is developed by employing the Ir-catalyzed decarboxylative phosphorothiolation of N-hydroxyphthalimide esters. This novel synthesis method utilizes carboxylic acids as raw material, which is stable, cheap, and commercially available. Scope studies show that this reaction has good compatibility of functional groups. Notably, both the synthesis of steric hindrance phosphorothioates and the later modification of some bioactive compounds are successfully achieved.

N-Chlorosuccinimide-promoted synthesis of thiophosphates from thiols and phosphonates under mild conditions

A very simple N-chlorosuccinimide-promoted synthesis of thiophosphates through the coupling of thiols and phosphonates is reported. Notably, the reactions were carried out in the absence of a base. Functional groups including fluoro, bromo and trifluoromethyl are all tolerated by the reaction conditions employed. Both aryl and alkyl thiols are coupled smoothly with a broad spectrum of phosphonates to afford the corresponding thiophosphates in good to excellent yields.

Reaction of N-(Cyclohexylthio)phthalimide with Phosphorus Acids

Reaction of N-(cyclohexylthio)phthalimide with phosphorous and dithiophosphoric acid esters yields phthalimide, its alkyl derivatives, and S-cyclohexyl thio- and trithiophosphates.