70591-86-5

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromobenzoylacetonitrile is used as an intermediate in the synthesis of pharmaceuticals for its ability to facilitate various chemical reactions, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Bromobenzoylacetonitrile serves as an intermediate in the production of agrochemicals, aiding in the synthesis of compounds that are used in pest control and crop protection.
Used in Organic Synthesis:
3-Bromobenzoylacetonitrile is used as a versatile building block in organic synthesis for its capacity to engage in multiple chemical reactions, enabling the creation of a wide range of organic compounds.
Used in Material Science:
3-BROMOBENZOYLACETONITRILE is utilized in the development of new materials, taking advantage of its chemical properties to enhance or create innovative material technologies.
Used as a Precursor in Fluorescent Dyes and Pharmaceuticals:
3-Bromobenzoylacetonitrile is used as a precursor in the production of fluorescent dyes and pharmaceuticals, capitalizing on its chemical structure to produce specialized compounds for various applications, including medical imaging and therapeutics.

InChI:InChI=1/C9H6BrNO/c10-8-3-1-2-7(6-8)9(12)4-5-11/h1-3,6H,4H2

Upstream product

• 6952-59-6 3-cyanobromobenzene 
• 75-05-8 acetonitrile 
• 1711-09-7 3-bromobenzoyl chloride 
• 151-50-8 potassium cyanide 
• 18523-22-3 2,3'-dibromoacetophenone 
• 24398-88-7 ethyl 3-bromobenzoate 
• 18293-53-3 2-trimethylsilylacetonitrile 
• 591-18-4 1-Bromo-3-iodobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 585-76-2 m-bromobenzoic acid 
• 773837-37-9 sodium cyanide 
• 89598-96-9 (3-bromophenyl)boronic acid 
• 109-77-3 malononitrile 
• 948883-31-6 3-(3-bromo-phenyl)-3-chloro-acrylonitrile 

Downstream Products

• 485812-87-1 3-(3-bromobenzoyl)-6-methyl-2-pyridone 
• 149246-81-1 3-(3-bromophenyl)-1H-pyrazol-5-amine 
• 935678-13-0 3-(3-bromophenyl)-2-methyl-3-oxopropanenitrile 
• 119162-52-6 3-(3-bromophenyl)-1,2-oxazol-5-amine 
• 1435943-36-4 methyl 5-cyano-6-(3-bromophenyl)-2-hydroxy-4-phenyl-3,4-dihydro-2H-pyran-2-carboxylate 
• 1435943-43-3 methyl 5-cyano-6-(3-bromophenyl)-2-hydroxy-4-(2,6-dichlorophenyl)-3,4-dihydro-2H-pyran-2-carboxylate 
• 1610051-93-8 C₁₆H₉Br₂N₃O 

Relevant academic research and scientific papers

Deadly KCN and pricey metal free track for accessing β-ketonitriles employing mild reaction conditions

A one pot synthesis of β-ketonitriles from readily accessible 3-chloropropenals using economically benign iodine, aqueous ammonia and sodium hydroxide solution, employing mild reaction conditions have been described. This report presents a convenient, inexpensive, highly toxic-matter-free and eco-friendly approach for β-ketonitriles.

Selective Synthesis of β-Ketonitriles via Catalytic Carbopalladation of Dinitriles

A practical, convenient, and highly selective method of synthesizing β-ketonitriles from the Pd-catalyzed addition of organoboron reagents to dinitriles has been developed. This method provides excellent functional-group tolerance, a broad scope of substrates, and the convenience of using commercially available substrates. The method is expected to show further utility in future synthetic procedures.

One-Pot Four-Component Coupling Approach to Polyheterocycles: 6 H-Furo[3,2- f]pyrrolo[1,2- d][1,4]diazepine

A novel polyheterocyclic chemical space, 6H-furo[3,2-f]pyrrolo[1,2-d][1,4]diazepine, was generated by a one-pot four-component coupling reaction where multiple bonds (three C-C, one C-O, and one C-N) were formed through a domino sequence. Two heterocyclic rings (furan and diazepine) were sequentially constructed from the monocyclic pyrrole derivative under environment-friendly reaction conditions to furnish the tricyclic fused scaffold.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

One-pot synthesis of benzoylacetonitriles through sequential Pd-catalyzed carbonylation and decarboxylation

Benzoylacetonitrile were prepared through sequential carbonylation and decarboxylation. The palladium-catalyzed carbonylation of aryl iodides and methyl cyanoacetate using Mo(CO)6 as a carbon monoxide source afforded beta-keto cyanoesters, and then the subsequent reaction with Li/H2O produced the desired benzoylacetonitriles.

PYRAZOLOPYRIMIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

PYRAZOLOPYRIMIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

PYRAZOLOPYRIMIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compound

Cascade synthesis of 3-aza-bicyclo[3.1.0]hex-2-ene derivatives from N-allyl enamines

An efficient iodine-mediated cascade synthesis of 3-aza-bicyclo[3.1.0]hex-2-ene derivatives from easily prepared N-allyl enamines has been developed. The advantages of the reaction include facilitative preparation of substrates 3a-t, good functional group tolerance and transition-metal-free conditions.

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

The disclosure generally relates to compounds of formula (I), including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compou