706-02-5Relevant academic research and scientific papers
Organylzinc chalcogenolate promoted michael-type addition of α,β-unsaturated carbonyl compounds
Loren Nunes, Vanessa,De Oliveira, Ingryd Cristina,Soares Do Rego Barros, Olga
supporting information, p. 1525 - 1530 (2014/03/21)
We present the chemo-, regio-, and stereoselective synthesis of vinyl chalcogenide compounds promoted by organylzinc chalcogenolates. In this protocol, reductive cleavage of diorganyl dichalcogenide bonds by the Zn/NH 4OH system led to organylz
Organylzinc Chalcogenolate Promoted Michael-Type Addition of α,β-Unsaturated Carbonyl Compounds
L?ren Nunes, Vanessa,De Oliveira, Ingryd Cristina,Soares Do Rêgo Barros, Olga
supporting information, p. 1525 - 1530 (2015/10/05)
We present the chemo-, regio-, and stereoselective synthesis of vinyl chalcogenide compounds promoted by organylzinc chalcogenolates. In this protocol, reductive cleavage of diorganyl dichalcogenide bonds by the Zn/NH4OH system led to organylzi
DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS
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Page/Page column 255; 256, (2013/04/13)
The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
Palladium-Catalyzed Synthesis of (Z)-3-Arylthioacrylic Acids and Thiochromenones
Palani, Thiruvengadam,Park, Kyungho,Song, Kwang Ho,Lee, Sunwoo
, p. 1160 - 1168 (2013/05/21)
The three-component reaction of aryl halides, sodium sulfide pentahydrate (Na2S×5 H2O), and propiolic acid in the presence of 2.5% bis(triphenylphosphine)palladium chloride [Pd(PPh3) 2Cl2], 5% 1,4-bis(diphenylphosphino)butane (dppb) and 2equivalents of 1,8-diazabicycloundec-7-ene (DBU) produces stereoselectively (Z)-3-arylthioacrylic acids in good yields. A study of the reaction pathway suggested that the C-S bond formation between aryl halides and Na 2S×5 H2O proceeded first, and the resulting intermediate reacted with propiolic acid to produce the desired product. In addition, when the resulting product was treated with acid, the respective thiochromenones were formed in good yields. Copyright
DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS
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Paragraph 0989; 0990, (2013/04/10)
The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
Pharmaceutical compositions containing acrylic acid derivatives and their use in the medicine
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, (2008/06/13)
Known acrylic acid derivatives of formula wherein, n is an integer of from 0 to 2,R represents a hydrogen, an alkaline or an alkaline earth metal atom, or a C1 4alkyl-group, and, R1 represents a hydrogen or a halogen atom or a C
INTRAMOLECULAR DIELS-ALDER CYCLOADDITIONS OF SUBSTITUTED FURFURYL E-2-(PHENYLSULFONYL)ACRYLATES
Jung, Michael E.,Truc, Vu Chi
, p. 6059 - 6062 (2007/10/02)
Several substituted furfuryl E-2-(phenylsulfonyl)acrylates have been prepared by direct routes and cyclized in good yield under very mild conditions to give highly oxidized systems of potential use in natural products synthesis.
Effect of Catalyst and Solvent on the Stereochemistry of Diels-Alder Reactions Between Cyclopentadiene and 3-Phenylsulfinylprop-2-enoic Acids and Methyl Esters
Proust, Simone M.,Ridley, Damon M.
, p. 1677 - 1688 (2007/10/02)
In Diels-Alder reactions between cyclopentadiene and the isomeric 3-phenylsulfinylprop-2-enoic acids and methyl esters, greatest stereoselectivity (94percent d.e.) results when methyl (Z)-3-phenylsulfinylprop-2-enoate (7) and benzene solvent are used.The
