711-29-5Relevant articles and documents
Styrene sulfone NLRP3 inflammasome inhibitor, preparation method and application thereof
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Paragraph 0053; 0078-0081; 0090-0091, (2020/10/30)
The invention relates to the field of styrene sulfone compounds and NLRP3 inhibitors, and particularly provides a styrene sulfone NLRP3 inflammasome inhibitor, a preparation method and application thereof, wherein the inhibitor is represented by a formula (1), n is selected from 0 and 1, X is selected from N and O, R1 is selected from different electron withdrawing or electron donating substituents, and R2 is selected from different fat or aromatic substituents. According to the invention, it is verified that the compounds represented by the general formula have NLRP3 inhibitory activity.
Design and Synthesis of Novel 4-Phenoxyquinolines Bearing 3-Hydrosulfonylacrylamido or 1H-Imidazole-4-carboxamido Scaffolds as c-Met Kinase Inhibitors
Wang, Jiao,Xie, Lijun,Wang, Yu,Wang, Xiaoqiang,Xi, Shuancheng,Zeng, Tianfang,Gong, Ping,Zhai, Xin
, (2017/02/15)
A series of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing (E)-3-hydrosulfonylacrylamido or 1H-imidazole-4-carboxamido moieties were designed, synthesized and evaluated for their cytotoxicity against A549, MKN-45, and HT-29 cancer cell lines in vitro. All the target compounds showed moderate to significant cytotoxic activity against the tested cells with IC50 values ranging from 0.13 to 2.65 μM. Five of them were further examined for their inhibitory activity against c-Met kinase, which identified compound 30 as a promising agent (c-Met IC50 = 1.52 nM) with IC50 values of 0.24, 0.45, and 0.13 μM against HT-29, MKN-45, and A549 cells, respectively.
Aza vinyl sulfones: Synthesis and evaluation as antiplasmodial agents
Glória, Paulo M.C.,Gut, Jiri,Gonalves, Lídia M.,Rosenthal, Philip J.,Moreira, Rui,Santos, Maria M.M.
body text, p. 7635 - 7642 (2012/01/05)
A series of novel aza vinyl sulfones were designed, synthesized in good yields and evaluated as antiplasmodial agents. Tested compounds did not show activity against papain or the Plasmodium falciparum cysteine protease falcipain-2. However, a number of t
An economical and convenient synthesis of vinyl sulfones
Guan, Zheng-Hui,Zuo, Wei,Zhao, Lian-Biao,Ren, Zhi-Hui,Liang, Yong-Min
, p. 1465 - 1470 (2008/02/05)
A general process for the efficient synthesis of vinyl sulfones has been developed using commercially available sulfinic acid sodium salts and dibromides. A variety of phenyl and methyl vinyl sulfones have been formed in good yields, in the absence of any catalyst. Georg Thieme Verlag Stuttgart.
7-Oxanorbornane and norbornane mimics of a distorted β-D- mannopyranoside: Synthesis and evaluation as β-mannosidase inhibitors
Buser, Stephan,Vasella, Andrea
, p. 3151 - 3173 (2007/10/03)
The racemic 7-oxanorbornanyl and norbornanyl aminoalcohols 3, 4, 42, 45, and 46 were synthesized and tested as snail β-mannosidase inhibitors. The amino tetraol 3 was obtained from the known sulfonyl acrylate 9 and furan 10. Esterification provided 11 tha
Pharmaceutical compositions containing acrylic acid derivatives and their use in the medicine
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, (2008/06/13)
Known acrylic acid derivatives of formula wherein, n is an integer of from 0 to 2,R represents a hydrogen, an alkaline or an alkaline earth metal atom, or a C1 4alkyl-group, and, R1 represents a hydrogen or a halogen atom or a C
INTRAMOLECULAR DIELS-ALDER CYCLOADDITIONS OF SUBSTITUTED FURFURYL E-2-(PHENYLSULFONYL)ACRYLATES
Jung, Michael E.,Truc, Vu Chi
, p. 6059 - 6062 (2007/10/02)
Several substituted furfuryl E-2-(phenylsulfonyl)acrylates have been prepared by direct routes and cyclized in good yield under very mild conditions to give highly oxidized systems of potential use in natural products synthesis.
