70646-97-8Relevant academic research and scientific papers
Substitutions on Pyridines Activated by Oxazolines via Nucleophilic Additions or Metalation-Alkylation
Meyers, A. I.,Gabel, Richard A.
, p. 2633 - 2637 (2007/10/02)
Pyridyloxazolines, derived from nicotinic acid or isonicotinic acid, have been shown to metalate at the 4- and 3-positions, respectively.These react with a variety of electrophiles to provide 4- and 3-substituted pyridines in good yield.Alternatively, 3-pyridyloxazolines, when treated with organolithium or Grignard reagents, give addition to the 4-position and provide a series of 4-substituted 1,4-dihydropyridines.
