70659-84-6Relevant academic research and scientific papers
Copper-Catalyzed Carbonylative Synthesis of Aliphatic Amides from Alkanes and Primary Amines via C(sp3)-H Bond Activation
Li, Yahui,Zhu, Fengxiang,Wang, Zechao,Wu, Xiao-Feng
, p. 5561 - 5564 (2016)
Amides are important intermediates and building blocks in organic synthesis. Among the known preparation procedures, aminocarbonylation is an interesting and powerful tool. However, most of the studies were focused on noble metal-catalyzed synthesis of ar
Selective formation of secondary amides via the copper-catalyzed cross-coupling of alkylboronic acids with primary amides
Rossi, Steven A.,Shimkin, Kirk W.,Xu, Qun,Mori-Quiroz, Luis M.,Watson, Donald A.
supporting information, p. 2314 - 2317 (2013/06/05)
For the first time, a general catalytic procedure for the cross-coupling of primary amides and alkylboronic acids is demonstrated. The key to the success of this reaction was the identification of a mild base (NaOSiMe3) and oxidant (di-tert-butyl peroxide) to promote the copper-catalyzed reaction in high yield. This transformation provides a facile, high-yielding method for the monoalkylation of amides.
