93098-08-9

Upstream product

• 119-52-8 4,4'-dimethoxybenzoin 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 120-44-5 1,4-di(4-methoxyphenyl)ethanone 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 67295-41-4 3,4-bis-(4-methoxy-phenyl)-4-oxo-butyric acid 
• 67820-94-4 3,4-bis(4-methoxyphenyl)-6-chloropyridazine 
• 70768-92-2 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one 
• 433330-77-9 5,6-bis-(4-methoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Mono- and di-substituted 5,6-diphenyl-3-alkylaminopyridazines active as ACAT inhibitors

A series of mono- or di-para-substituted 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. The compound which combines a chlorine atom on the 6-phenyl ring and a n-hexylamino chain showed a significant enhancement of activity with respect to the unsubstituted derivative. Attempts to correlate the activity of the compounds to their structural features, also through theoretical calculations, are reported.

An Unusual Reaction of a Phosphorane with Benzoins: Formation of 1,2-Dicarbonyl and 1,4-Dicarbonyl Compounds

Benzoins (1a-e) on reaction with carbethoxymethylenetriphenylphosphorane (2) furnish hydroxy esters (3a-e) and butenolides (4a and 4e) along with the unusual products, benzils (5a-e) and ketoesters (6a-e) as major product.