7078-90-2

Usage

Uses

Used in Pharmaceutical Synthesis:
(5-BROMO-2-METHOXY-BENZYL)-DIMETHYL-AMINE is used as an intermediate in the synthesis of pharmaceuticals for its ability to modify the properties of other molecules, which is crucial in the development of new drugs and medicinal compounds.
Used in Organic Chemistry Reactions:
In the field of organic chemistry, (5-BROMO-2-METHOXY-BENZYL)-DIMETHYL-AMINE is used as a reagent for processes such as amine alkylation and reductive amination, facilitating the formation of new chemical bonds and the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
(5-BROMO-2-METHOXY-BENZYL)-DIMETHYL-AMINE is utilized in medicinal chemistry as a molecule modifier, enhancing the effectiveness, selectivity, or stability of drug candidates by altering their chemical structures.
Used in Controlled Environments:
Due to its potential reactivity and toxicity, (5-BROMO-2-METHOXY-BENZYL)-DIMETHYL-AMINE is used in controlled environments for safe handling and storage, ensuring the safety of personnel and the integrity of the compound during research and production processes.

InChI:InChI=1/C10H14BrNO/c1-12(2)7-8-6-9(11)4-5-10(8)13-3/h4-6H,7H2,1-3H3

Upstream product

• 7017-52-9 4-bromo-2-(chloromethyl)-1-methoxybenzene 
• 124-40-3 dimethyl amine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 33797-51-2 eschenmoser's salt 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 80866-82-6 5-bromo-2-methoxy-benzyl alcohol 

Downstream Products

• 505070-85-9 1-(3-dimethylaminomethyl-4-methoxyphenyl)ethanone 
• 628311-20-6 3-dimethylaminomethyl-4-methoxy-benzaldehyde 

Relevant academic research and scientific papers

Metalations utilizing aryllithiums; ortho-functionalization of p-bromoanisole (pBrA)

An ortho-metalation protocol has been developed, which permits the survival of a bromine substituent in p-bromoanisole. Eight derivatives of the generated ortho-lithiated intermediate have been prepared. A neglected metalation concept is being explored here; one which proposes that minimizing the pKa difference between the aryl substrate and the conjugate acid of the metalating agent will lead to a regiospecific and selective metalation process.

Cationic chalcone antibiotics. Design, synthesis, and mechanism of action

This paper describes how the introduction of "cationic" aliphatic amino groups in the chalcone scaffold results in potent antibacterial compounds. It is shown that the most favorable position for the aliphatic amino group is the 2-position of the B-ring, in particular in combination with a lipophilic substituent in the 5-position of the B-ring. We demonstrate that the compounds act by unselective disruption of cell membranes. Introduction of an additional aliphatic amino group in the á-ring results in compounds that are selective for bacterial membranes combined with a high antibacterial activity against both Gram-positive and -negative pathogens. The most potent compound in this study (78) has an MIC value of 2 μM against methicillin resistant Staphylococus aureus.