70821-32-8Relevant academic research and scientific papers
Synthesis and biological evaluation of some hydrazones and carbazones of indane-l,3-dione
Jubie,Meenab,Ramaseshu,Jawahar,Vijayakumar
experimental part, p. 1261 - 1263 (2010/12/25)
Diethyl phthalate on treatment with ethyl acetate in sodium ethoxide gives sodium salt of ester derivative, which on neutralization in presence of sulphuric acid affords indane-1,3-dione 1. Various hydrazines and carbazides on condensation with 1 in ethanol under reflux furnish the corresponding hydrazones and carbazones 2a-g. The structures of the compounds have been established by IR and 'H NMR spectral data. All the synthesized compounds have been evaluated for their anticoagulant and antimicrobial activities. Among these, compounds 2b and 2c have shown significant anticoagulant activity. All the compounds exhibited mild to moderate antimicrobial activities. Among these compounds 2a and 2g are found to have antimicrobial activities comparable to that of standard drugs used.
The Regiospecific Synthesis of N-Substituted Pyrazoles. I. 1- and 2-Substituted Indenopyrazol-4(1H)-ones
Lemke, Thomas L.,Sawhney, Kailash N.
, p. 1335 - 1340 (2007/10/02)
The reaction of enaminoketones (2 or 5) of 2-acyl-1,3-indandiones with unsymmetrical hydrazines results in the regiospecific synthesis of 1,3- or 2,3-disubstituted indenopyrazol-4(1H)-ones (4 or 7).The synthesis of the enaminoketones (2 or 5) is accomplished by way of amine addition to the 2-acyl-1,3-indandiones 8a-c or by reduction of the indenoisoxazole 9.The structural assignment of the isomeric indenopyrazoles 4 and 7 is based upon 1H-nmr chemical shifts.
