70862-56-5

Basic information

• Product Name: 5-(4-fluorophenyl)-3-(trifluoromethyl)isoxazole
• Synonyms: 5-(4-fluorophenyl)-3-(trifluoromethyl)isoxazole
• CAS NO: 70862-56-5
• Molecular Weight: 231.149
• Mol File: 70862-56-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(4-fluorophenyl)-3-(trifluoromethyl)isoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-fluorophenyl)-3-(trifluoromethyl)isoxazole(70862-56-5)
• EPA Substance Registry System: 5-(4-fluorophenyl)-3-(trifluoromethyl)isoxazole(70862-56-5)

Safety Data

• Hazardous Substances Data: 70862-56-5(Hazardous Substances Data)

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 753-90-2 trifluoroethylamine 
• 582-65-0 1-(4-fluorophenyl)-4,4,4-trifluoro-1,3-butanedione 

Downstream Products

• 170569-88-7 mavacoxib 

Relevant articles and documents

Method for preparing 3-trifluoromethylisooxazole compound by one-pot

The invention discloses a novel method for preparing a 3-trifluoromethylisooxazole compound by one-pot. According to the method, trifluoroethylamine which can be purchased in markets is prepared intofluorinated diazomethane, and then the fluorinated diazomethane and an alkynes compound are in coupled reaction under catalysis of low-price copper. The method is simple to operate, reaction conditions are mild, the cost is low, by-products are fewer, the yield is high, tolerance of a functional group is high, and reaction can be amplified. Meanwhile, much deeper mechanism study is carried out, and a mechanism that a trifluoromethyl ketoximes compound intermediate may be produced in the reaction is proposed.

Studies in potential organo-fluorine antibacterial agents. Part 2: Synthesis and antibacterial activity of some new fluorine-containing 3.5-disubstituted isoxazoles

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