70886-33-8

Basic information

• Product Name: 5-NITRO-1,3-BENZOXAZOLE
• Synonyms: 5-NITRO-1,3-BENZOXAZOLE;5-Nitrobenzoxazole
• CAS NO: 70886-33-8
• Molecular Formula: C₇H₄N₂O₃
• Molecular Weight: 164.12
• Mol File: 70886-33-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 127-129°
• Boiling Point: 294.2°C at 760 mmHg
• Flash Point: 131.7°C
• Appearance: /
• Density: 1.473g/cm³
• Vapor Pressure: 0.0029mmHg at 25°C
• Refractive Index: 1.658
• Storage Temp.: 2-8°C
• PKA: -5.69±0.10(Predicted)
• CAS DataBase Reference: 5-NITRO-1,3-BENZOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO-1,3-BENZOXAZOLE(70886-33-8)
• EPA Substance Registry System: 5-NITRO-1,3-BENZOXAZOLE(70886-33-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 70886-33-8(Hazardous Substances Data)

Usage

Uses

5-Nitrobenzoxazole is a useful reactant for copper-catalyzed direct carboxylation of C-H bonds in benzoxazoles and related compounds with carbon dioxide.

InChI:InChI=1/C7H4N2O3/c10-9(11)5-1-2-7-6(3-5)8-4-12-7/h1-4H

Upstream product

• 273-53-0 benzoxazole 
• 70886-35-0 N-(2-hydroxy-5-nitrophenyl)formamide 
• 99-57-0 2-hydroxy-5-nitroaniline 
• 122-51-0 orthoformic acid triethyl ester 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 39835-09-1 5-nitro-2-hydroxybenzonitrile 
• 891-43-0 5-nitro-2-phenylbenzo[d]oxazole 
• 112606-69-6 3-(4'-Methyl)phenyl-5-nitro-benzisoxazole 
• 49559-61-7 5-Nitrobenzoxazol-2-carbonsaeuremethylester 
• 49559-67-3 5-nitro-benzooxazole-2-carboxylic acid 
• 1400811-41-7 C₁₅H₈N₂O₃ 
• 144037-41-2 5-nitro-2-phenethylbenzo[d]oxazole 
• 112606-72-1 2-(4-bromophenyl)-5-nitro-1,3-benzoxazole 
• 962-25-4 2-(4-chlorophenyl)-5-nitrobenzo[d]oxazole 
• 212758-55-9 2-(4-fluorophenyl)-5-nitrobenzo[d]oxazole 
• 1033-85-8 2-(4'-methoxyphenyl)-5-nitrobenzoxazole 

Relevant articles and documents

ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE "RIG-I' PATHWAY AND METHODS OF USE THEREOF

The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.

Method for synthesizing benzoxazole through microwave radiation of benzamide compound in water phase

The invention discloses a method for synthesizing benzoxazole through microwave radiation of a benzamide compound in a water phase. The benzamide compound is added into the water phase under the microwave condition to be subjected to a cyclization reaction for generating the benzoxazole under the alkali condition, and the method for preparing the benzoxazole is environmentally friendly, easy and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be applied to a large number of functional groups, the yield is high, the number of by-products is small, and the method is easy to operate, safe, low in cost and environmentally friendly. (Please see the specifications for the formula).

SUBSTITUTED SPIROCYDIC INHIBITORS OF AUTOTAXIN

The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.