70894-75-6

Basic information

• Product Name: ISOPROPYL-(4-METHYL-BENZYL)-AMINE
• Synonyms: 4-Methyl-N-(1-methylethyl)benzenemethanamine;isopropyl-(4-methylbenzyl)amine hydrochloride;N-(p-tolylmethyl)propan-2-amine hydrochloride;N-[(4-methylphenyl)methyl]propan-2-amine hydrochloride;ISOPROPYL-(4-METHYL-BENZYL)-AMINE;CHEMBRDG-BB 4017387;N-(4-METHYLBENZYL)PROPAN-2-AMINE;N-(4-METHYLPHENYLMETHYL)ISOPROPYLAMINE
• CAS NO: 70894-75-6
• Molecular Formula: C₁₁H₁₇N
• Molecular Weight: 163.26
• Mol File: 70894-75-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 229℃
• Flash Point: 89℃
• Appearance: /
• Density: 0.903
• Vapor Pressure: 0.072mmHg at 25°C
• Refractive Index: 1.503
• PKA: 10.00±0.19(Predicted)
• CAS DataBase Reference: ISOPROPYL-(4-METHYL-BENZYL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: ISOPROPYL-(4-METHYL-BENZYL)-AMINE(70894-75-6)
• EPA Substance Registry System: ISOPROPYL-(4-METHYL-BENZYL)-AMINE(70894-75-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 70894-75-6(Hazardous Substances Data)

Usage

General Description

ISOPROPYL-(4-METHYL-BENZYL)-AMINE is an organic chemical compound with the molecular formula C11H17N. It is a derivative of amine, with a benzyl group and an isopropyl group attached to the nitrogen atom. ISOPROPYL-(4-METHYL-BENZYL)-AMINE is often used as a building block in organic synthesis and pharmaceutical manufacturing. It has applications in the production of various pharmaceuticals and agrochemicals as a versatile intermediate. ISOPROPYL-(4-METHYL-BENZYL)-AMINE is known for its ability to undergo various chemical reactions, making it a valuable component in the chemical industry.

InChI:InChI=1/C11H17N/c1-9(2)12-8-11-6-4-10(3)5-7-11/h4-7,9,12H,8H2,1-3H3

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 75-31-0 isopropylamine 
• 108-18-9 diisopropylamine 
• 104-84-7 para-methylbenzylamine 
• 104-85-8 para-methylbenzonitrile 
• 67-63-0 isopropyl alcohol 
• 959571-89-2 N-isopropyl-N-(4-methylbenzyl)propan-2-amine 
• 2144-17-4 N-isopropyl-4-methylbenzamide 
• 156697-63-1 2-(bromomethyl)-1-<(4-methylphenyl)methyl>aziridine 
• 1252059-64-5 2-(methoxymethyl)-1-(4-methylbenzyl)aziridine 
• 17556-67-1 isopropyl-[(4-methylphenyl)meth-(E)ylidene]amine 

Downstream Products

• 55246-43-0 C₁₂H₁₆ClNO 

Relevant articles and documents

Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production

Despite a myriad of available pharmacotherapies for the treatment of type 2 diabetes (T2D), challenges still exist in achieving glycemic control. Several novel glucose-lowering strategies are currently under clinical investigation, highlighting the need f

Transformation of N,N-diisopropylarylmethylamines into N-isopropylarylmethylamines with molecular iodine

N,N-Diisopropylarylmethylamines were smoothly converted into the corresponding N-isopropylarylmethylamines by the reaction with molecular iodine in the presence of Na2CO3 in chloroform at 60 °C. Other related tertiary amines were also transformed into the corresponding secondary amines by the reaction with molecular iodine under the same reaction conditions.

Microwave-assisted regioselective ring opening of non-activated aziridines by lithium aluminium hydride

A new synthetic protocol for the LiAlH4-promoted reduction of non-activated aziridines under microwave conditions was developed. Thus, ring opening of 2-(acetoxymethyl)aziridines provided the corresponding β-amino alcohols, which were then used as eligible substrates in the synthesis of 5-methylmorpholin-2-ones via condensation with glyoxal in THF. The same procedure was applied for the preparation of novel 5(R)- and 5(S)-methylmorpholin-2-ones starting from the corresponding enantiopure 2-(hydroxymethyl)aziridines. Additionally, 2-(methoxymethyl)- and 2-(phenoxymethyl)aziridines were treated with LiAlH4 under microwave irradiation, giving rise to either isopropylamines or 1-methoxypropan-2-amines depending on the reaction conditions.