70900-95-7Relevant academic research and scientific papers
OLIGODEOXYRIBONUCLEOTIDE SYNTHESIS BY USE OF S,S-DIPHENYL DEOXYRIBONUCLEOSIDE 3'-PHOSPHORODITHIOATES AND BIFUNCTIONAL CONDENSING REAGENTS IN THE PHOSPHOTRIESTER APPROACH
Sekine, Mitsuo,Matsuzaki, Jun-Ichi,Hata, Tsujiaki
, p. 5279 - 5288 (2007/10/02)
Four kinds of arenedisulphonyl chlorides as condensing reagents for oligodeoxyribonucleotide synthesis have been synthesised and their condensing abilities were examined in the synthesis of thymidylyl(3'-5')thymidine.Among them, mesitylenedisulphonyl chlo
4,4',4''-Tris(levulinoyloxy)trityl as a New Type of Primary Hydroxyl Protecting Group
Sekine, Mitsuo,Hata, Tsujiaki
, p. 336 - 339 (2007/10/02)
The 4,4',4''-tris(levulinoxy)trityl (TLTr) group was introduced selectively on the 5'-oxygen of thymidine by use of in situ generated 4,4',4''-tris(levulinoyloxy)trityl bromide.The TLTr group was found to be sufficiently stable to acids and readily removed by hydrazinolysis followed by warming to 50 deg C in pyridine-acetic acid without damage of other protecting groups such as the O-acetyl and 4,4'-dimethoxytrityl groups.The utility of this new protecting group was demonstrated by the successful synthesis of thymidylyl(3'-5')thymidine where the TLTr group was employed as 5'-hydroxyl-protecting group.
Cyclic Orthoester Functions as New Protecting Groups in Nucleosides
Sekine, Mitsuo,Hata, Tsujiaki
, p. 2044 - 2049 (2007/10/02)
Four kinds of cyclic orthoester functions have been studied as protecting groups of hydroxyl groups in nucleosides.Among them, the 1,3-benzodithiol-2-yl (BDT) group was found to have several promising properties.This group can be easily introduced into nu
PHOSPHOTRIESTER APPROACH TO OLIGOTHYMIDYLATE SYNTHESIS UTILIZING A SIMPLE THYMIDINE UNIT AND A NEW TYPE OF CONDENSING AGENT
Sekine, Mitsuo,Matsuzaki, Jun-ichi,Hata, Tsujiaki
, p. 3209 - 3212 (2007/10/02)
DMTrTp(SPh)2 was proposed as a simplest "nucleotide unit" for the synthesis of olygothymidylates.One phenylthio group was removed selectively and rapidly from dithiol-esters by 1M pyridinium hypophosphonate.Two kinds of arenedisulfonyl chlorides were newl
Synthesis and Properties of S,S-Diaryl Thymidine Phosphorodithioates
Sekine, Mitsuo,Hamaoki, Ken,Hata, Tsujiaki
, p. 3815 - 3827 (2007/10/02)
Appropriately protected and unprotected S,S-diphenyl thymidine 3'- or 5'-phosphorodithioates and S,S-bis(4-methoxyphenyl) thymidine 3'- or 5'-phosphorodithioates were successfully prepared by the reaction of the thymidine derivatives with cyclohexylammoni
