70905-45-2

Usage

Uses

Used in Organic Synthesis:
1-CHLORO-2-(CHLOROMETHYL)-3,5-DIOXAHEXANE is used as a synthetic intermediate for the production of various organic compounds. Its unique structure allows for further chemical reactions, making it a versatile building block in the synthesis of a wide range of molecules.
Used in Pharmaceutical Industry:
1-CHLORO-2-(CHLOROMETHYL)-3,5-DIOXAHEXANE is used as a key component in the development of new pharmaceuticals. Its reactivity and functional groups enable the creation of novel drug candidates with potential therapeutic applications.
Used in Chemical Research:
1-CHLORO-2-(CHLOROMETHYL)-3,5-DIOXAHEXANE is utilized in chemical research to study various reaction mechanisms and to develop new synthetic methods. Its properties and reactivity make it an interesting subject for scientific investigation.

InChI:InChI=1/C5H10Cl2O2/c1-8-4-9-5(2-6)3-7/h5H,2-4H2,1H3

Upstream product

• 107-30-2 chloromethyl methyl ether 
• 106-89-8 epichlorohydrin 
• 67-56-1 methanol 
• 53883-86-6 2-(chloromethoxy)-1,3-dichloropropane 
• 109-87-5 Dimethoxymethane 
• 96-23-1 1,3-Dichloro-2-propanol 

Downstream Products

• 109-87-5 Dimethoxymethane 
• 18587-81-0 bis-(β,β'-dichloro-isopropoxy)-methane 
• 110874-21-0 2-(methoxymethoxy)-1,3-propanediyl dibenzoate 
• 105104-40-3 Okahara's reagent 
• 76089-31-1 1,1'-oxydi(propan-2-one) 
• 83171-86-2 cyclohexyl acetonyl ether 
• 621-87-4 3-phenoxy-2-propanone 
• 661490-75-1 (R)-3-[(S)-2-((R)-1-Benzyloxymethyl-allyloxy)-4-methoxymethoxy-pent-4-enoyl]-4-isopropyl-oxazolidin-2-one 
• 661490-74-0 (S)-3-[(R)-2-((R)-1-Benzyloxymethyl-allyloxy)-4-methoxymethoxy-pent-4-enoyl]-4-isopropyl-oxazolidin-2-one 
• 661490-77-3 (R)-3-{(S)-2-[(S)-1-(2-Benzyloxy-ethyl)-allyloxy]-4-methoxymethoxy-pent-4-enoyl}-4-isopropyl-oxazolidin-2-one 
• 661490-76-2 (S)-3-{(R)-2-[(S)-1-(2-Benzyloxy-ethyl)-allyloxy]-4-methoxymethoxy-pent-4-enoyl}-4-isopropyl-oxazolidin-2-one 
• 110874-22-1 2-(acetoxymethoxy)-1,3-propanediyl dibenzoate 
• 86357-13-3 2-(acetoxymethoxy)-1,3-propanediyl diacetate 
• 105104-43-6 1-phenoxy-2-methylene-3,5-dioxahexane 

Relevant academic research and scientific papers

Novel nucleoside analogues as effective antiviral agents for Zika virus infections

Previously considered a neglected flavivirus, Zika virus has recently emerged as a public health concern due to its ability to spread rapidly and cause severe neurological disorders, such as microcephaly in newborn babies from infected mothers, and Guilla

HYDROXY-PROTECTING REAGENT AND METHOD OF PROTECTING HYDROXY WITH THE SAME

The present invention relates to a method of protecting a hydroxyl group, which includes reacting a hydroxyl group-containing compound with a compound represented by the formula (I) : wherein R is a phenyl group optionally having substituent(s), an alkyl

A unified approach to the enantioselective synthesis of 2,6-cis and trans disubstituted tetrahydropyranones

A stereoselective construction of cis- and trans-2,6-disubstituted tetrahydropyranones, based on strategy which combines an asymmetric alkylation and ring closing metathesis for the formation of a cyclic enol ether, is reported.

A Facile, General Approach to the Synthesis of Electrophilic Acetone Equivalents

The facile, high-yielding, yet general synthesis of electrophilic chloroacetone equivalents 11a-f is described. The enol ethers are assembled in three steps starting with trichloride 29 in overall yields of 57-93%. Nucleophilic displacement of the chloromethyl chlorine with a range of organometallic reagents generates dichlorides 30 in yields of 58-99%, which can be dehydrohalogenated with t-BuOK/THF in yields of 87-99% to produce enol ethers 31. Conversion of the allyl chlorides 31 to the corresponding allyl iodides 11 with 72-99% yield completes the synthetic sequence. The entire sequence can be performed in less than 48 h on a 50 mmol scale.

An efficient synthesis of 2-[(4-amino-1,2-dihydro-2-oxo-1- pyrimidinyl)methoxy]-1,3-propanediyl-di-L-valinate an anti-cytomegalovirus agent

An efficient synthesis for large scale preparation of the titled compound, a prodrug for the anti-HCMV agent 1-[2-hydroxy-1- (hydroxymethyl)ethoxy)methyl]cytosine, 9, has been developed. The product of each step is easily purified by either distillation o

On the Hodge Mechanism of the Bread Flavor Component 6-Acetyl-1,2,3,4-tetrahydropyridine from Proline and Sugars

The so-called Hodge mechanism for the generation of 6-acetyl-1,2,3,4-tetrahydropyridine, a major Maillard flavor compound in processed foods, from proline and 1,2-propanedione most probably does not involve the intermediacy of N-acetonyl-4-aminobutanal.This finding is based on model experiments in which suitably and doubly protected N-acetonyl-4-aminobutanal was hydrolyzed into the parent compound and in which no trace of the flavor compound could be detected.Keywords: Bread flavor; Maillard reaction; Hodge mechanism; 6-acetyl-1,2,3,4-tetrahydropyridine; flavor formation

Effect of Acyclic Pyrimidines Related to 9-guanine on Herpesviruses

A series of pyrimidines related to the potent antiherpetic agent 9-guanine (1, BW B759U), all containing the same acyclic chain, have been synthesized.Some of the compounds were derivatives of the naturally occuring bases, cytosine, uracil, and thymine; others included compounds in which the 5-position of the cytosine and uracil moieties were substituted by bromo, iodo, fluoro, methyl, and amino groups.Other variations of the cytosine derivatives were the 5-aza, 2-mercapto, 4-methylamino, 4-dimethylamino, and isocytosine congeners.A 4-aminopyrimidine adduct was also made.Antiviral testing showed that 1-cytosine (18, BW A1117U) was equivalent to the guanine analogue in the potency against human cytomegalovirus and Epstein Barr virus.Other compounds in the series were largely inactive in antiviral screening against the herpesviruses.

Regioselective Addition of Organic Chlorides to Epoxides in the Presence of Quaternary Ammonium Chloride

By a reaction of epoxides with organic chlorides in the presence of dodecyltrimethylammonium chloride as a catalyst, a series of 2-substituted 1-(chloromethyl)ethyl ethers were synthesized regioselectively in high yields under mild conditions.