70991-57-0

Basic information

• Product Name: 4-(3-methylthiophen-2-yl)acetophenone
• Synonyms: 4-(3-methylthiophen-2-yl)acetophenone
• CAS NO: 70991-57-0
• Molecular Weight: 216.304
• Mol File: 70991-57-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(3-methylthiophen-2-yl)acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-methylthiophen-2-yl)acetophenone(70991-57-0)
• EPA Substance Registry System: 4-(3-methylthiophen-2-yl)acetophenone(70991-57-0)

Safety Data

• Hazardous Substances Data: 70991-57-0(Hazardous Substances Data)

Upstream product

• 616-44-4 3-Methylthiophene 
• 99-92-3 p-aminobenzophenone 
• 110-46-3 isopentyl nitrite 
• 99-90-1 para-bromoacetophenone 
• 41784-08-1 4-acetylbenzenaminium hydrochloride 

Downstream Products

• 79040-44-1 methyl[1-[4-(3-methyl-2-thienyl)phenyl]ethylidene]cyanoacetate 
• 70991-85-4 5-[4-(3-methyl-thien-2-yl)phenyl]5-methylhydantoin 
• 70991-60-5 2-[4-(3-methyl-thien-2-yl)phenyl]propionaldehyde 

Relevant articles and documents

Palladium-catalysed C2 or C5 direct arylation of 3-substituted thiophenes with aryl bromides

The Pd(OAc)2/dppb system was found to be an efficient catalyst for the direct arylation of 3-substituted thiophene derivatives. The regioselectivity of the arylation strongly depends on the thiophene substituent and also on the nature of the aryl bromide. When using 3-formyl, 3-cyano, 3-methyl, 3-hydroxymethyl or 3-bromothiophene, the 2-arylated thiophenes were obtained with 76-95% regioselectivity; whereas, the arylation of 3-formylthiophene diethylacetal or 3-acetylthiophene gave the 5-arylated thiophenes with 52-90% regioselectivity. The use of congested aryl bromides favours the arylation at C5. These reactions were performed using only 0.1 mol% of catalyst. Moreover, this procedure has been found to be tolerant to a variety of functional groups on the aryl bromide such as formyl, propionyl, benzoyl, nitrile, and nitro. Georg Thieme Verlag Stuttgart.