71022-84-9

Basic information

• Product Name: 3'-Nitro-[1,1'-biphenyl]-2-ol
• Synonyms: 3'-Nitro-[1,1'-biphenyl]-2-ol;2-(3-Nitrophenyl)phenol
• CAS NO: 71022-84-9
• Molecular Formula: C₁₂H₉NO₃
• Molecular Weight: 215.20476
• Mol File: 71022-84-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 99.5-100 °C
• Boiling Point: 373.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.304±0.06 g/cm3(Predicted)
• PKA: 9.20±0.35(Predicted)
• CAS DataBase Reference: 3'-Nitro-[1,1'-biphenyl]-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-Nitro-[1,1'-biphenyl]-2-ol(71022-84-9)
• EPA Substance Registry System: 3'-Nitro-[1,1'-biphenyl]-2-ol(71022-84-9)

Safety Data

• Hazardous Substances Data: 71022-84-9(Hazardous Substances Data)

Usage

General Description

3'-Nitro-[1,1'-biphenyl]-2-ol, also known as 3'-nitro-2-hydroxy-1,1'-biphenyl, is a chemical compound with the molecular formula C12H9NO3. It is a yellow solid that is insoluble in water but soluble in organic solvents. 3'-Nitro-[1,1'-biphenyl]-2-ol is commonly used as a nitrophenol derivative in organic synthesis and pharmaceutical intermediates. It has been identified as a potential environmental pollutant and may pose health hazards if ingested or inhaled. 3'-Nitro-[1,1'-biphenyl]-2-ol has also been studied for its potential antimicrobial and anticancer properties.

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Downstream Products

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Relevant articles and documents

Microwave-Promoted Pd-Catalyzed Synthesis of Dibenzofurans from Ortho-Arylphenols

ortho-Aryl phenols, synthesized via protecting group free Suzuki–Miyaura coupling of ortho-halophenols and arene boronic acids, undergo a cyclization to dibenzofurans via oxidative C–H activation. The reaction proceeds under microwave irradiation in short reaction times using catalytic amounts of Pd(OAc)2 without additional ligands.

Palladium-catalyzed direct arylation of phenols with aryl iodides

An efficient protocol of palladium-catalyzed direct para-arylation of unfunctionalized phenols with aryl iodides under mild conditions was reported. A variety of substrates were applied in this reaction with yields up to 87%.

Copper-catalyzed oxidative aromatization of 2-cyclohexen-1-ones to phenols in the presence of catalytic hydrogen bromide under molecular oxygen

Catalytic oxidative aromatization has been achieved using 2-cyclohexen-1-ones to obtain phenol derivatives in the presence of a catalytic amount of copper salt and aqueous HBr under molecular oxygen. The amount of HBr was successfully reduced to a catalytic quantity, and the other additive such as a ligand and an oxidant as well as inert conditions were unnecessary. Various mono-, di-, and trisubstituted phenols with substituents at the desired positions could be synthesized under cheap and simple conditions. An oxidative aromatization/bromination sequence was also demonstrated to obtain bromophenols with excess HBr. The Royal Society of Chemistry 2013.