71176-75-5Relevant academic research and scientific papers
2-(Aminomethyl)phenols, a New Class of Saluretic Agents. 4. Effects of Oxygen and/or Nitrogen Substitution
Stokker, G. E.,Deana, A. A.,deSolms, S. J.,Schultz, E. M.,Smith, R. L.,et al.
, p. 735 - 742 (2007/10/02)
A series of oxygen and/or nitrogen substituted 2-(aminomethyl)phenols was synthesized and tested orally in rats for saluretic and diuretic effects.Intravenous dog data are included as supplementary material to demonstrate diuretic responses, or lack thereof, in a secon species.In general, substitution on nitrogen with groups other than lower alkyl or substitution on nitrogen and/or oxygen with groups resistant to hydrolysis substantially diminished or ablated saluretic effects.
Nuclear substituted 2-hydroxyphenylmethanesulfamic acids
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, (2008/06/13)
Nuclear substituted 2-hydroxyphenylmethanesulfamic acids and their pharmaceutically acceptable salts wherein the phenyl nucleus is substituted with 2 to 4 nuclear substituents and which are useful saluretic-diuretics and anti-inflammatories are disclosed.
