71072-30-5

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Chloro-acetyl)-piperidin-4-one is used as an antihypertensive agent for the treatment of high blood pressure and heart failure. Its application is based on its ability to inhibit the angiotensin-converting enzyme (ACE), which leads to the relaxation of blood vessels and a reduction in the workload on the heart.
Additionally, 1-(2-Chloro-acetyl)-piperidin-4-one has been studied for its potential anti-cancer and anti-inflammatory properties, making it a promising candidate for further research and potential drug development in the fields of oncology and immunology.

Upstream product

• 848438-60-8 N-chloroacetyl-4-hydroxypiperidine 
• 41661-47-6 piperidin-4-one 
• 79-04-9 chloroacetyl chloride 

Relevant academic research and scientific papers

Synthesis and in vitro antileishmanial efficacy of novel quinazolinone derivatives

Currently available drugs being used to treat leishmaniasis have several shortcomings, including high toxicity, drug administration that requires hospitalization, and the emergence of parasite resistance against clinically used drugs. As a result, there is a dire need for the development of new antileishmanial drugs that are safe, affordable, and efficient. In this study, two new series of synthesized quinazolinone derivatives were investigated as potential future antileishmanial agents, by assessing their activities against the Leishmania (L.) donovani and L.?major species. The cytotoxicity profiles of these derivatives were assessed in vitro on Vero cells. The compounds were found to be safer and without any toxic activities against mammalian cells, compared to the reference drug, halofuginone, a clinical derivative of febrifugine. However, they had demonstrated poor antileishmanial growth inhibition efficacies. The two compounds that had been found the most active were the mono quinazolinone 2d and the bisquinazolinone 5b with growth inhibitory efficacies of 35% and 29% for the L.?major and L.?donovani 9515 promastigotes, respectively. These outcomes had suggested structural redesign, inter alia the inclusion of polar groups on the quinazolinone ring, to potentially generate novel quinazolinone derivatives, endowed with effective antileishmanial potential.

Nanoscale molecular rods with a new building block for solubility enhancement

(Chemical Equation Presented) A new building block bearing a [1,3]dioxolo[4,5-f][1,3]benzodioxole core was developed to enhance the solubility of molecular rods by lateral alkyl chains. On incorporation in molecular rods with oligospiroketal structure, the straight geometry is retained, which was concluded from the X-ray crystal structure analysis of one of the rods. The determination of the solubility of a collection of rods bearing this building block revealed that already a butyl group efficiently hinders the aggregation of the rods and consequently causes a considerable enhancement of the solubility. Piperidine rings are located at the ends of the rods, which offer the opportunity for versatile functionalization. Thus, an N,N′-bis(azidoacetyl)-functionalized rod was prepared, which could serve as rigid linkage, initiated by a "Click" reaction.