71082-47-8

Basic information

• Product Name: 6-Methoxy-3- quinolinecarboxvlic acid
• Synonyms: 6-Methoxy-3- quinolinecarboxvlic acid;3-Carboxy-6-methoxyquinoline;6-Methoxy-3- quinolinecarboxvli;6-Methoxy-3-quinolinecarboxylic acid
• CAS NO: 71082-47-8
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.2
• Mol File: 71082-47-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 385.421°C at 760 mmHg
• Flash Point: 186.896°C
• Appearance: /
• Density: 1.325g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.648
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-Methoxy-3- quinolinecarboxvlic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methoxy-3- quinolinecarboxvlic acid(71082-47-8)
• EPA Substance Registry System: 6-Methoxy-3- quinolinecarboxvlic acid(71082-47-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 71082-47-8(Hazardous Substances Data)

Usage

General Description

6-Methoxy-3-quinolinecarboxylic acid is a chemical compound that belongs to the quinolinecarboxylic acid family. It is also known as 6-Methyl-3-methoxyquinoline-4-carboxylic acid or 3-Carboxy-6-methoxyquinoline. 6-Methoxy-3- quinolinecarboxvlic acid is a derivative of quinoline and is often used in the synthesis of pharmaceuticals and agrochemicals. It has potential biological activity and is being studied for its potential therapeutic applications, particularly in the treatment of cancer and infectious diseases. 6-Methoxy-3-quinolinecarboxylic acid is also used as a building block in organic synthesis and as a research tool in the field of medicinal chemistry.

InChI:InChI=1/C11H9NO3/c1-15-9-2-3-10-7(5-9)4-8(6-12-10)11(13)14/h2-6H,1H3,(H,13,14)

Upstream product

• 40131-09-7 diethyl methoxymethylenemalonate 
• 104-94-9 4-methoxy-aniline 
• 77156-78-6 ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate 
• 22931-71-1 ethyl 4-chloro-6-methoxyquinolin-3-carboxylate 
• 26660-48-0 ethyl 6-methoxyquinoline-3-carboxylate 

Downstream Products

• 1137826-05-1 6-hydroxyquinoline-3-carboxylic acid 
• 1350750-73-0 methyl 6-phenoxyquinoline-3-carboxylate 
• 71083-30-2 6-methoxyquinoline-3-carboxamide 
• 426842-85-5 4-chloro-3-fluoro-6-methoxyquinoline 
• 29507-86-6 3-amino-6-methoxyquinoline 

Relevant articles and documents

Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid

A scalable route to 3-fluoro-6-methoxyquinoline needed to be developed as multi-kg amounts of this heterocycle were required. Initial route development focused on the formation of the key C-F bond via a Balz-Schiemann reaction or electrophilic fluorinatio

Syntheses and Reactions of Diazepinoquinolines

Three routes for the preparation of diazepinoquinolines (1) have been studied.The best yields resulted by starting from the amides of N-(3-quinolylcarbonyl)-N-alkyl-amino acids (5).Quaternization to 9, intramolecular cyclization under the influence of base to 10, oxidation to 11 and debenzylation by catalytic hydrogenation gave 1. - Keywords: Quinolinium Salts, Cyclization Reaction