Bioorganic and Medicinal Chemistry Letters p. 1487 - 1490 (2003)
Update date:2022-08-05
Topics:
Zask
Gu
Albright
Du
Hogan
Levin
Chen
Killar
Sung
DiJoseph
Sharr
Roth
Skala
Jin
Cowling
Mohler
Barone
Black
March
Skotnicki
Potent and selective bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors were synthesized by a novel convergent route. Selectivity and efficacy versus MMPs and TACE could be controlled by appropriate substitution on the scaffolds and by variation of the P1′ group. Select compounds were found to be effective in in vivo models of arthritis.
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