71088-00-1Relevant academic research and scientific papers
Enantioselective Synthesis of Isoxazolines Enabled by Palladium-Catalyzed Carboetherification of Alkenyl Oximes
Chen, Mingjie,Li, Wenbo,Wang, Lei,Wang, Yuzhuo,Zhang, Junliang,Zhang, Kenan
supporting information, p. 4421 - 4427 (2020/02/11)
Reported here is a highly efficient Pd/Xiang-Phos catalyzed enantioselective carboetherification of alkenyl oximes with either aryl or alkenyl halides, delivering various chiral 3,5-disubstituted and 3,5,5-trisubstituted isoxazolines in good yields with u
Pd-catalyzed carboetherification ofβ,γ-unsaturated oximes: A novel approach to δ2-lsoxazolines
Jiang, Dahong,Peng, Jinsong,Chen, Yuanwei
supporting information; experimental part, p. 1695 - 1698 (2009/04/12)
A novel route to the synthesis of δ2-isoxazoline derivatives is described. Reaction of β,γ-unsaturated oximes with aryl bromides via palladium-catalyzed carboetherification affords 3,5-disubstituted δ2-isoxazollnes in good yields. The use of Xantphos as ligand Is crucial for the transformation. The carboetherification products can be further converted to β-hydroxy ketones in the presence of Fe powder and NH4CI.
