711-47-7

Upstream product

• 3187-58-4 methyl orsellinate 
• 83324-59-8 3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde 
• 67-56-1 methanol 
• 30448-89-6 3-chloro-4,6-dihydroxy-2-methylbenzoic acid 

Downstream Products

• 68048-11-3 3,5-dibenzyloxy-2-chlorotoluene 
• 69769-50-2 methyl 3-chloro-6-(3,5-dichloro-2-hydroxy-4-methoxy-6-methylphenoxy)-4-hydroxy-2-methylbenzoate 
• 69709-91-7 3,5,5'-trichloro-2,2',4,4'-tetrahydroxy-6,6'-dimethylbenzophenone 
• 69709-89-3 3,5,5'-trichloro-2,2',4'-trihydroxy-4-methoxy-6,6'-dimethylbenzophenone 
• 78135-51-0 3-chloro-6-(3,5-dichloro-2-hydroxy-4-methoxy-6-methylphenoxy)-4-hydroxy-2-methylbenzoic acid 
• 78135-36-1 2,2',4'-tribenzyloxy-3,5,5'-trichloro-4-methoxy-6,6'-dimethylbenzophenone 
• 78135-39-4 2,2',4,4'-tetrabenzyloxy-3,5,5'-trichloro-6,6'-dimethylbenzophenone 
• 1559072-16-0 N-(but-3-en-1-yl)-3-chloro-4,6-di(ethoxymethoxy)-N-methyl-2-(2-oxodec-9-en-1-yl)benzamide 
• 1559072-18-2 C₂₆H₃₈ClNO₆ 
• 1007313-79-2 3-chloro-4,6-bis(ethoxymethoxy)-2-methylbenzoic acid 
• 1559072-02-4 3-chloro-4,6-di(ethoxymethoxy)-2-(2-oxooct-7-en-1-yl)benzoic acid 
• 1559072-12-6 N-(but-3-en-1-yl)-3-chloro-4,6-di(ethoxymethoxy)-N-methyl-2-(2-oxooct-7-en-1-yl)benzamide 
• 1559072-05-7 C₂₂H₃₁ClO₇ 
• 1559072-08-0 C₂₃H₃₃ClO₇ 

Relevant academic research and scientific papers

Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties

DNA-encoded chemical libraries are increasingly used to identify leads for drug discovery or chemical biology. Despite the resurging interest in covalent inhibitors, libraries are typically designed with synthon filtered out for reactive functionalities that can engage a target through covalent interactions. Herein, we report the synthesis of two libraries containing Michael acceptors to identify cysteine reactive ligands. We developed a simple procedure to discriminate between covalent and high affinity non-covalent inhibitors using DNA display of the library in a microarray format. The methodology was validated with known covalent and high affinity non-covalent kinase inhibitors. Screening of the library revealed novel covalent inhibitors for MEK2 and ERBB2.

DIHYDROOROTIC ACID DEHYDROGENASE INHIBITOR

The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R1 represents a hydrogen atom, R2 represents an alkyl group containing 1 to 7 carbon atoms, R3 represents -CHO, and R4 represents -CH2-CH=C(CH3)-R0 (wherein R0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti-H. pylori agent, a therapeutic agent for diabetes or the like.

NOVEL DIHYDROXYBENZENE DERIVATIVES AND ANTIPROTOZOAL AGENT COMPRISING SAME AS ACTIVE INGREDIENT

Novel compounds below are useful for preventing or treating diseases caused by protozoans. At least one of a compound represented by Formula (I) (wherein, X represents a hydrogen atom or a halogen atom; R1 represents a hydrogen atom; R2 represents a hydrogen atom or a C1-7 alkyl group; R3 represents -CHO, -C(=O)R5, -COOR5 (wherein R5 represents a C1-7 alkyl group), -CH2OH or -COOH; and R4 represents a C1-16 alkyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), a C2-16 alkenyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), or a C2-16 alkynyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s)), an optical isomer thereof, and a pharmaceutically acceptable salt is used.

Total synthesis of graphislactone G

We present a total synthesis of the fungal natural product graphislactone G, a chlorinated resorcylic lactone. The key step is a Suzuki coupling used for the construction of the central biaryl bond. Graphislactone G was prepared in 13 steps with 22% yield