7111-64-0

Usage

Uses

Used in Agriculture:
4-(3,4-Dichlorophenyl)benzoic acid is used as a herbicide for controlling the growth of unwanted plants. It is effective in managing various types of weeds, thereby improving crop yield and quality.
Used in Chemical Synthesis:
4-(3,4-DICHLOROPHENYL)BENZOIC ACID serves as an intermediate in the synthesis of other chemicals, contributing to the production of various industrial and consumer products.
Used in Environmental Management:
4-(3,4-Dichlorophenyl)benzoic acid is utilized in environmental management practices to control invasive plant species, thus helping to maintain ecological balance and prevent damage to natural habitats.
Safety and Disposal:
4-(3,4-Dichlorophenyl)benzoic acid is considered a moderately hazardous substance. It is crucial to follow appropriate safety precautions when handling 4-(3,4-DICHLOROPHENYL)BENZOIC ACID, such as wearing protective gear and working in well-ventilated areas. Additionally, proper disposal methods should be adhered to in accordance with local regulations to minimize environmental impact.

Upstream product

• 18282-59-2 4-bromo-1,2-dichlorobenzene 
• 180516-87-4 4-carboxyphenylboronic acid pinacol ester 
• 95-50-1 1,2-dichloro-benzene 
• 926254-63-9 1-(3',4'-dichloro[1,1']biphenyl-4-yl)ethanone 
• 94-09-7 p-aminoethylbenzoate 
• 7111-65-1 3',4'-Dichlor-4-biphenyl-carbonsaeure-aethylester 

Relevant academic research and scientific papers

Synthesis of chlorinated biphenyls by Suzuki cross-coupling using diamine or diimine-palladium complexes

Several novel diimines (Salen-type ligands) 2a-2i and their reduced diamine counterparts 3b,3d-3g and 3i form complexes 4a-4i, 5b,5d-5g, and 5i with PdCl2 in DMF or methanol. Using 1 mol-% of the isolated complexes 4e and 5f many polychlorinated biphenyls (PCBs) can be prepared in moderate to excellent yields according to the Suzuki cross-coupling protocol with contact to air. Several 4-acetylbiphenyls prepared by this method can be converted in moderate yields into the corresponding biphenylcarboxylic acids (BCAs) by alkaline cleavage. An X-ray crystal structure determination confirms the structure of complex 5f. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture

The present invention relates to carboxamide compounds of general formula I wherein the groups and residues A, B, W, X, Y, Z, R1, R2, R3 and k have the meanings given in claim 1. Moreover the invention relates to process for preparing the above mentioned carboxamides as well as pharmaceutical compositions containing at least one carboxamide according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

N-acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.

N-Acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula Are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.

NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein

The E2 protein is required for the replication of human papillomaviruses (HPVs), which are responsible for anogenital warts and cervical carcinomas. Using an NMR-based screen we tested compounds for binding to the DNA-binding domain of the HPV-E2 protein. Three classes of compounds were identified which bound to two distinct sites on the protein. Biphenyl and biphenyl ether compounds containing a carboxylic acid bind to a site near the DNA recognition helix and inhibit the binding of E2 to DNA. Benzophenone- containing compounds which lack a carboxylic acid group bind to the β- barrel formed by the dimer interface and exhibit negligible effects on the binding of E2 to DNA. Structure-activity relationships from the biphenyl and biphenyl ether compounds were combined to produce a compound [5-(3'- (3'',5''-dichlorophenoxy)-phenyl)-2,4-pentadienoic acid] with an IC50 value of approximately 10 μM. This compound represents a useful lead for the development of antiviral agents that interfere with HPV replication and further illustrates the usefulness of the SAR by NMR method in the drug discovery process.