71126-62-0

Usage

InChI:InChI=1/C10H15NO/c1-11-7-8-12-9-10-5-3-2-4-6-10/h2-6,11H,7-9H2,1H3

Upstream product

• 17229-17-3 benzyl 2-chloroethyl ether 
• 74-89-5 methylamine 
• 27058-15-7 N-benzyl-2-(benzyloxy)-N-methylethan-1-amine 
• 60656-87-3 benzyloxyacetoaldehyde 
• 100-39-0 benzyl bromide 
• 54555-84-9 benzyl iodoethyl ether 

Downstream Products

• 66046-63-7 N-(2-benzyloxy-ethyl)-N'-(2-chloro-ethyl)-N-methyl-phosphorodiamidic acid but-3-enyl ester 
• 883973-92-0 (S)-2-[3-(2-Benzyloxy-ethyl)-3-methyl-ureido]-3-phenyl-propionic acid methyl ester 
• 883973-36-2 (S)-2-[3-(2-Benzyloxy-ethyl)-3-methyl-ureido]-3-phenyl-propionic acid 
• 883973-47-5 2-[3-(2-benzyloxy-ethyl)-3-methyl-ureido]-N-methoxy-N-methyl-3-phenyl-propionamide 
• 66046-66-0 2-[(2-benzyloxy-ethyl)-methyl-amino]-3-(2-chloro-ethyl)-2-oxo-2λ⁵-[1,3,2]oxazaphosphinan-4-one 
• 168274-64-4 1-(2-benzyloxyethyl)-4,4-dideuteroimidazolidin-2-one 

Relevant academic research and scientific papers

Synthesis of Diverse N-Acryloyl Azetidines and Evaluation of Their Enhanced Thiol Reactivities

Acyl azetidines exhibit nonplanar hybridization, leading to lower amide-like character of the corresponding (O)C-N bonds. This impacts N-acryloyl azetidines by producing enhanced electrophilicy at appended Michael acceptors. Herein, reactivity data are reported in the presence of glutathione (GSH) in phosphate buffer (pH 7.4) at 37 °C. Wide reactivity ranges are observed by varying substitution at the Michael acceptor or by modulating the electron-withdrawing character of substituents at the C3 position of the azetidine.

QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS

Compounds of formula (I) that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS

Compounds that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for

A novel series of urea-based peptidomimetic calpain inhibitors

A series of peptide aldehyde derivatives in which the P2 chiral carbon has been replaced with nitrogen were synthesized as urea-based peptidomimetic inhibitors of μ-calpain. The compounds mirrored the general SAR of peptidyl aldehyde calpain inhibitors but displayed greater selectivity for μ-calpain over cathepsin B.

Chemoselective deprotection of teriary benzylamines and reduction of carbon-carbon double bonds in the presence of benzyl and benzyloxymethyl ethers

Catalytic transfer hydrogenation using 10% Pd-C in the presence of 1,4-cyclohexadiene as the hydrogen donor selectively debenzylates amines and reduces carbon-carbon double bonds while leaving benzyl and benzyloxymethyl ethers intact. (C) 2000 Elsevier Sc

PHENYL INDOLE COMPOUNDS

The present invention relates to phenylindole compounds of formula I: STR1 related to atypical neuroleptic sertindole.