71173-20-1Relevant articles and documents
Catalyst- and Additive-Free Chemoselective Transfer Hydrogenation of α-Keto Amides to α-Hydroxy Amides by Sodium Formate
Hao, Feiyue,Gu, Zhenyu,Liu, Guyue,Yao, Wubing,Jiang, Huajiang,Wu, Jiashou
, p. 5985 - 5991 (2019/09/10)
A catalyst- and additive-free chemoselective transfer hydrogenation of α-keto amides to α-hydroxy amides is easily achieved by using sodium formate as a hydrogen source. The utility of this method is demonstrated by gram-scale synthesis and transformation of the resultant α-hydroxy amides into polysubstituted acetamides and 2-arylindole derivatives. Control experiments suggest that the NH group of α-keto amides is crucial for the chemoselective reduction through the formation of hydrogen bonds.
Efficient copper(II)-catalyzed transamidation of non-activated primary carboxamides and ureas with amines
Zhang, Min,Imm, Sebastian,Baehn, Sebastian,Neubert, Lorenz,Neumann, Helfried,Beller, Matthias
supporting information; experimental part, p. 3905 - 3909 (2012/06/04)
Amid(e) them all: Primary carboxamides and ureas react with aromatic and aliphatic amines in the presence of a copper catalyst to give a wide range of functionalized amides (see scheme). Copyright
