7118-66-3

Basic information

• Product Name: 5-METHYL-2-P-TOLYL-1H-BENZO[D]IMIDAZOLE
• Synonyms: 5-METHYL-2-P-TOLYL-1H-BENZO[D]IMIDAZOLE;1H-BenziMidazole, 6-Methyl-2-(4-Methylphenyl)-1H-BenziMidazole, 5-Methyl-2-(4-Methylphenyl)- (9CI);5-Methyl-2-(4-Methylphenyl)benziMidazole, 95%;6-Methyl-2-p-tolyl-1H-benzo[d]iMidazole;5-Methyl-2-p-tolyl-1H-benzoimidazole
• CAS NO: 7118-66-3
• Molecular Formula: C₁₅H₁₄N₂
• Molecular Weight: 222.29
• Mol File: 7118-66-3.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 415.8°C at 760 mmHg
• Flash Point: 215.9°C
• Appearance: /Solid
• Density: 1.152g/cm³
• Vapor Pressure: 4.02E-07mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: 5-METHYL-2-P-TOLYL-1H-BENZO[D]IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-2-P-TOLYL-1H-BENZO[D]IMIDAZOLE(7118-66-3)
• EPA Substance Registry System: 5-METHYL-2-P-TOLYL-1H-BENZO[D]IMIDAZOLE(7118-66-3)

Safety Data

• Hazardous Substances Data: 7118-66-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H14N2/c1-10-3-6-12(7-4-10)15-16-13-8-5-11(2)9-14(13)17-15/h3-9H,1-2H3,(H,16,17)

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Relevant articles and documents

Synthesis and evaluation of 2-aryl-1H-benzo[d]imidazole derivatives as potential microtubule targeting agents

Microtubule targeting agents (MTAs) are the potential drug candidates for anticancer drug discovery. Disrupting the microtubule formation or inhibiting the de-polymerization process by a synthetic molecule can lead to an excellent anticancer drug candidat

Copper-Mediated Diamination of Arylboronic Acids for the Synthesis of 2-Aryl Benzimidazoles Using Trimethylsilyl Azide as the Amino Sources with Aldehydes

A direct and versatile copper-mediated three-component reaction of arylboronic acids, trimethylsilyl azide and aldehydes for the synthesis of benzimidazoles is reported. The reaction is well tolerated by a wide range of substituted aromatic aldehydes and aromatic boronic acids to produce the corresponding benzimidazoles in moderate to high yields. Mechanism investigations demonstrated that copper-promoted Chan-Evans-Lam coupling, C?H amination, and oxidative cycloaddition are involved in the tandem processes. (Figure presented.).

Aerobic {Mo72V30} nanocluster-catalysed heterogeneous one-pot tandem synthesis of benzimidazoles

A novel heterogeneous one-pot protocol is developed for tandem aerobic synthesis of benzimidazoles through dehydrogenative coupling of primary benzylic alcohols and aromatic diamines co-catalysed by Keplerate-type {Mo72V30} polyoxometalate and N-hydroxyphthalimide (NHPI). The catalytic system also works well for the synthesis of benzimidazoles using benzaldehydes, as commonly used starting materials, in the absence of NHPI. The high activity of the solid nanocluster provides standard conditions avoiding current limitations of oxidation methods including high catalyst loadings. The spectral results and leaching experiments revealed that the nanocapsule preserved its structural integrity after being reused in consecutive runs.