71186-85-1

Usage

Uses

Used in Pharmaceutical and Organic Compounds Synthesis:
3,4-diMethoxy-4'-Fluorobenzophenone is used as a key intermediate in the synthesis of various pharmaceutical and organic compounds. Its unique structure allows for the creation of new molecules with potential therapeutic and functional properties.
Used in Cosmetic Products:
3,4-diMethoxy-4'-Fluorobenzophenone is used as a UV filter in sunscreens and other cosmetic products. Its ability to absorb ultraviolet radiation helps protect the skin from harmful UV rays, reducing the risk of sunburn and skin damage.
Used in Organic Electronics and Materials Science:
Due to its unique properties, 3,4-diMethoxy-4'-Fluorobenzophenone has potential applications in the field of organic electronics and materials science. It can be used in the development of new materials with specific electronic properties, such as conductivity or light emission.
Safety Precautions:
It is important to handle 3,4-diMethoxy-4'-Fluorobenzophenone with caution as it may cause skin and eye irritation. It should be stored in a cool, dry place away from heat and sources of ignition to prevent any potential hazards.

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 403-43-0 4-fluorobenzoyl chloride 
• 456-22-4 4-Fluorobenzoic acid 
• 2859-78-1 4-Bromoveratrole 
• 98-86-2 acetophenone 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 

Downstream Products

• 203394-62-1 3-(3,4-Dimethoxyphenyl)-3-(4'-fluorophenyl)acrylonitrile 
• 1385825-43-3 (3,4-dimethoxyphenyl)(4-fluorophenyl)methanone oxime 
• 1496524-37-8 isopropyl((2S)-1-(((3,4-dimethoxylphenyl)(4-fluorophenyl)methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 
• 844856-32-2 (3,4-dimethoxyphenyl)(4-fluorophenyl)methanol 

Relevant academic research and scientific papers

2-Methyltetrahydrofuran (2-MeTHF): A Green Solvent for Pd?NHC-Catalyzed Amide and Ester Suzuki-Miyaura Cross-Coupling by N?C/O?C Cleavage

The palladium-NHC-catalyzed (NHC=N-heterocyclic carbene) Suzuki-Miyaura cross-coupling of amides and esters via highly chemoselective N?C(O) and O?C(O) cleavage with aryl boronic acids using green, sustainable and eco-friendly 2-methyltetrahydrofuran (2-MeTHF) is reported. A variety of amides and aryl esters were coupled with aryl boronic acids in high to excellent yields. This method employs commercially-available, air- and moisture-stable Pd(II) ?NHC precatalysts. Crucially, the use of 2-MeTHF leads to the highest TON reported to date in amide N?C(O) bond cross-coupling. This operationally-simple protocol was utilized in the synthesis a bioactive ketone intermediate, emphasizing the potential of 2-MeTHF as a green solvent in unconventional amide bond disconnection. Given the tremendous importance of amide bond cross-coupling strategies and the drive to maintain full sustainability in cross-coupling processes, we expect that the synthetic method will be of broad interest.

Palladium-Catalyzed suzuki?Miyaura cross-Coupling of amides via site-Selective n?C bond cleavage by cooperative catalysis

Palladium-catalyzed Suzuki?Miyaura cross-coupling of primary benzamides enabled by a merger of site-selective N,N-di-Boc-activation and cooperative catalysis via N?C bond cleavage for the synthesis of biaryl ketones is reported. We present the synergistic combination of Lewis base and palladium catalysis as a concept to activate inert amide N?C bonds. The mild reaction conditions provide a direct route to structurally diverse ketones. The reaction tolerates a wide range of electrophilic functional groups. Considering the fundamental importance of primary amides as pharmaceutical and synthetic intermediates, the strategy has a potential for developing a diverse array of valuable amide N?C bond functionalization reactions by the synergistic merger of Lewis base and organometallic catalysis.

Design, synthesis, and fungicidal activity of novel carboxylic acid amides represented by N-benzhydryl valinamode carbamates

Carboxylic acid amide (CAA) fungicides are an important class of agricultural fungicide with oomycete activity and low toxicity toward mammalian cells. To find CAA analogues with high activity against resistant pathogens, a series of substituted N-benzhydryl valinamide carbamate derivatives were designed and synthesized by introducing substituted aromatic rings into valinamide carbamate leads. Bioassays showed that some title compounds exhibited very good in vitro fungicidal activity against Phytophthora capsici and in vivo fungicidal activities against Pseudoperonospora cubensis. Topomer CoMFA was performed to explore the structure-activity relationship on the basis of the in vitro data. The dimethoxy substituted aromatic analogue 9e was found to display higher in vitro fungicidal activity against Phytophthora capsici than iprovalicarb but lower activity than mandipropamid, and higher in vivo fungicidal activity against Pseudoperonospora cubensis than dimethomorph at a dosage of 6.25 μg mL-1. This journal is the Partner Organisations 2014.

One-pot synthesis of diarylmethanones through palladium-catalyzed sequential coupling and aerobic oxidation of aryl bromides with acetophenone as a latent carbonyl donor

A one-pot palladium-catalyzed synthesis of symmetrical and unsymmetrical diarylmethanones using acetophenone and aryl bromides as raw materials has been developed. In this reaction, acetophenone acts as a latent carbonyl donor and two pathways of palladium-catalyzed sequential coupling and aerobic oxidation are identified. The reaction is applicable to a spectrum of substrates and delivers the products in moderate to good yields. This method can be used for the synthesis of ketoprofen, a nonsteroidal anti-inflammatory drug, in a two-step procedure and 45% overall yield.

Acrylic acid morpholides, fungicidal compositions and use

Compounds of the formula STR1 wherein A is STR2 B is STR3 R1 is hydrogen; halogen, cyano or optionally substituted C1-4 alkyl; and Q is NR8 R9 or STR4 where R2 to R11 are substituents of various types. The compounds are useful as fungicides.

Stereochemical aspects of the metabolism of 5-(4'-fluorophenyl)-5-phenylhydantoin in the rat

Racemic 5-(4'-fluorophenyl)-5-phenylhydantoin was synthesized to examine its metabolism in rat. This compound differs from the antiepileptic agent 5,5-diphenylhydantoin in that the normal site of hydroxylation in 5,5-diphenylhydantoin is blocked on one of the phenyl groups by a fluorine atom. The 4'-fluoro analogue gives a major metabolite, which was isolated and identified as (R)-(-)-5-(4'-fluorophenyl)-5-(4'-hydroxyphenyl)hydantoin of 37% enantiomeric purity. The absolute configuration and enantiomeric purity of the metabolite were determined by chemical conversion to (S)-(-)-5-(4'-hydroxyphenyl)-5-phenylhydantoin. A second metabolite of the catechol type, possibly as a mixture of 5-(3',4'-dihydroxyphenyl)-5-(4'-fluorophenyl)hydantoin, and the corresponding O-3'-methyl derivative was detected by gas chromatography-mass spectrometry after methylation.