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712-79-8

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712-79-8 Usage

Description

2-(difluoromethoxy)naphthalene is a chemical compound characterized by the molecular formula C12H8F2O. It is a white to light yellow solid that exhibits slight solubility in water. 2-(difluoromethoxy)naphthalene is recognized for its role as a versatile building block in the synthesis of a range of products, including pharmaceuticals, agrochemicals, aromatic compounds, dyes, pigments, and electronic materials.

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-(difluoromethoxy)naphthalene is utilized as a precursor in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and agricultural products.
Used in Organic Chemistry:
2-(difluoromethoxy)naphthalene serves as a reagent in organic chemistry reactions, facilitating the creation of complex molecules and structures that are essential in research and industry.
Used in Dye and Pigment Production:
2-(difluoromethoxy)naphthalene is employed in the production of dyes and pigments, enhancing the color properties and stability of these substances in various applications.
Used in Electronic Materials Manufacturing:
2-(difluoromethoxy)naphthalene is also used in the manufacturing of electronic materials, where its chemical properties may contribute to the performance and functionality of electronic devices.
Safety Considerations:
It is important to handle 2-(difluoromethoxy)naphthalene with care, as it may cause irritation to the skin, eyes, and respiratory system if not used properly, highlighting the need for appropriate safety measures during its application and handling.

Check Digit Verification of cas no

The CAS Registry Mumber 712-79-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,1 and 2 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 712-79:
(5*7)+(4*1)+(3*2)+(2*7)+(1*9)=68
68 % 10 = 8
So 712-79-8 is a valid CAS Registry Number.

712-79-8Downstream Products

712-79-8Relevant articles and documents

Redox-Neutral TEMPO Catalysis: Direct Radical (Hetero)Aryl C?H Di- and Trifluoromethoxylation

Lee, Johnny W.,Lim, Sanghyun,Maienshein, Daniel N.,Liu, Peng,Ngai, Ming-Yu

supporting information, p. 21475 - 21480 (2020/10/02)

Applications of TEMPO. catalysis for the development of redox-neutral transformations are rare. Reported here is the first TEMPO.-catalyzed, redox-neutral C?H di- and trifluoromethoxylation of (hetero)arenes. The reaction exhibits a broad substrate scope, has high functional-group tolerance, and can be employed for the late-stage functionalization of complex druglike molecules. Kinetic measurements, isolation and resubjection of catalytic intermediates, UV/Vis studies, and DFT calculations support the proposed oxidative TEMPO./TEMPO+ redox catalytic cycle. Mechanistic studies also suggest that Li2CO3 plays an important role in preventing catalyst deactivation. These findings will provide new insights into the design and development of novel reactions through redox-neutral TEMPO. catalysis.

Catalytic radical difluoromethoxylation of arenes and heteroarenes

Lee, Johnny W.,Zheng, Weijia,Morales-Rivera, Cristian A.,Liu, Peng,Ngai, Ming-Yu

, p. 3217 - 3222 (2019/03/21)

Intermolecular C-H difluoromethoxylation of (hetero)arenes remains a long-standing and unsolved problem in organic synthesis. Herein, we report the first catalytic protocol employing a redox-active difluoromethoxylating reagent 1a and photoredox catalysts for the direct C-H difluoromethoxylation of (hetero)arenes. Our approach is operationally simple, proceeds at room temperature, and uses bench-stable reagents. Its synthetic utility is highlighted by mild reaction conditions that tolerate a wide variety of functional groups and biorelevant molecules. Experimental and computational studies suggest single electron transfer (SET) from excited photoredox catalysts to 1a forming a neutral radical intermediate that liberates the OCF2H radical exclusively. Addition of this radical to (hetero)arenes gives difluoromethoxylated cyclohexadienyl radicals that are oxidized and deprotonated to afford the products of difluoromethoxylation.

A SIMPLE CONVENIENT METHOD FOR PREPARATION OF DIFLUOROMETHYL ETHERS USING FLUOROSULFONYLDIFLUOROACETIC ACID AS A DIFLUOROCARBENE PRECURSOR

Chen, Qing-Yun,Wu, Sheng-Wen

, p. 433 - 440 (2007/10/02)

In the presence of catalytic amounts of sodium sulfate or cuprous iodide, a variety of alkyl and aryl difluoromethyl ethers were synthesized in moderate yields by the reaction of the corresponding alcohols and phenols with fluorosulfonyldifluoroacetic acid (1) in acetonitrile under mild conditions.Fluorosulfonyldifluoroacetate anion (5) is believed to readily eliminate SO2, CO2 and F(1-), thus liberating CF2:; insertion of difluorocarbene into O-H bonds and its capture by fluorode ion then result in the formation of ethers and by-product CF3H, respectively.

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