71231-24-8

Basic information

• Product Name: 3-Phenyl-N-(o-tolyl)propanamide
• Synonyms: 3-Phenyl-N-(o-tolyl)propanamide;N-(2-methylphenyl)-3-phenylpropanamide
• CAS NO: 71231-24-8
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.32
• Mol File: 71231-24-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Phenyl-N-(o-tolyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenyl-N-(o-tolyl)propanamide(71231-24-8)
• EPA Substance Registry System: 3-Phenyl-N-(o-tolyl)propanamide(71231-24-8)

Safety Data

• Hazardous Substances Data: 71231-24-8(Hazardous Substances Data)

Upstream product

• 78987-21-0 N-(2-methylphenyl)-3-phenylacrylamide 
• 95-53-4 o-toluidine 
• 645-45-4 hydrocinnamic acid chloride 
• 100-42-5 styrene 
• 201230-82-2 carbon monoxide 
• 38282-01-8 N-[(E)-3-phenyl-2-propenyl]diethylamine 
• 501-52-0 3-Phenylpropionic acid 

Relevant articles and documents

Method for selective reduction α, β - unsaturated carbonyl compound carbon-carbon double bond (by machine translation)

The invention discloses a method for selectively reducing carbon-carbon double bonds in α and β - unsaturated carbonyl compounds, which comprises the following steps of adding α, β - unsaturated carbonyl compounds shown in formula (I) in an electrolysis system and reducing α and β - unsaturated carbonyl compounds with carbonyl-conjugated carbon-carbon double bonds through an electrochemical cathodic reduction reaction. Compared with the reported method, the method disclosed by the invention does not use a metal catalyst and an external oxidant; and the reaction raw material and the electrolyte are low in price, nontoxic and tasteless, simple and convenient in post-treatment. (by machine translation)

NIS-mediated oxidative arene C(sp2)-H amidation toward 3,4-dihydro-2(1H)-quinolinone, phenanthridone, and N-fused spirolactam derivatives

A new radical-mediated intramolecular arene C(sp2)-H amidation of 3-phenylpropanamides or [1,1′-biphenyl]-2-carboxamides was developed to prepare a series of 3,4-dihydro-2(1H)-quinolinone and phenanthridone derivatives in moderate to excellent yields (33-94%). Spirolactams could also be obtained using this protocol.

Organic ligand-free carbonylation reactions with unsupported bulk Pd as catalyst

Herein, surprising results for bulk Pd-catalyzed carbonylation reactions are presented. Three types of carbonylation reactions can be realized efficiently under organic ligand-free conditions, namely, hydroaminocarbonylation of olefins, aminocarbonylation of aryl iodides and oxidative carbonylation of amines, which almost cover all the known mechanisms in carbonylation reactions. Notably, the bulk Pd catalyst system exhibited better catalytic activity than the classical homogeneous PdCl2/(2-OMePh)3P catalyst system. This study will create a momentous and new field of green carbonylation reactions.

Rhodium-Catalyzed Asymmetric Synthesis of β-Branched Amides

A general asymmetric route for the one-step synthesis of chiral β-branched amides is reported through the highly enantioselective isomerization of allylamines, followed by enamine exchange, and subsequent oxidation. The enamine exchange allows for a rapid and modular synthesis of various amides, including challenging β-diaryl and β-cyclic.

Phosphorus oxychloride as an efficient coupling reagent for the synthesis of esters, amides and peptides under mild conditions

A mild method is described for the conversion of carboxylic acids into esters, amides, as well as peptides without racemization through carboxyl activation by the reagent combination of POCl3 and DMAP. Long chain alcohols could be converted to the corresponding ester in good yields. 31P NMR spectrum was used to detect phosphorus-containing intermediates in ongoing reactions directly, and a possible mechanism has been proposed based on these results. The Royal Society of Chemistry 2013.